649717-55-5

Upstream product

• 59-50-7 4-Chloro-3-methylphenol 
• 933-88-0 ortho-toluoyl chloride 

Downstream Products

• 137711-94-5 3-tert-butoxycarbonylamino-6-chloro-7-methyl-4-(2-methylphenyl)-2H-1-benzopyran-2-one 
• 137711-98-9 ethyl 6-chloro-7-methyl-4-(2-methylphenyl)-2-oxo-1-thiobenzopyran-3-carboxylate 
• 137711-61-6 ethyl 6-chloro-7-methyl-4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-3-carboxylate 
• 137711-75-2 6-chloro-7-methyl-4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid 
• 170799-07-2 5-chloro-4,2'-dimethyl-2-mercaptobenzophenone 
• 170799-04-9 5-chloro-2-hydroxy-4,2'-dimethylbenzophenone 

Relevant academic research and scientific papers

Synthesis of 3-ureido derivatives of coumarin and 2-quinolone as potent Acyl-CoA: Cholesterol acyltransferase inhibitors

Novel 3-ureido derivatives of 4-phenylcoumarin and 4-phenyl-2-quinolone were synthesized and evaluated for acyl-CoA: cholesterol acyltransferase (ACAT)-inhibitory activity. These derivatives inhibited rat intestinal ACAT with IC50 values at the 10-8 to 10-9 M level and were found to normalize plasma cholesterol levels in cholesterol-fed rats when administered as dietary admixtures.