64985-43-9Relevant academic research and scientific papers
Novel phthalimide derivatives, designed as leukotriene D4 receptor antagonists
Lima, Lídia M.,De Brito, Fernanda C.F.,De Souza, Simone D.,Miranda, Ana L.P.,Rodrigues, Carlos R.,Fraga, Carlos A.M.,Barreiro, Eliezer J.
, p. 1533 - 1535 (2002)
A series of phthalimide acid derivatives was synthesized and evaluated as leukotriene D4 receptor antagonists. The tetrazolephthalimide LASSBio 552 (7) was shown to be able to inhibit the contractile activity induced by 100 nM of LTD4 in guinea-pig tracheal strips with an IC50=31.2 μM. In addition, LASSBio 552 (7) has been showed to present a better efficacy than zafirlukast (1) used as standard.
O-alkylation of bioactive phthalimide derivatives under microwave irradiation in dry media
Lima, Lidia M.,Barreiro, Eliezer J.,Fraga, Carlos A. M.
, p. 3291 - 3306 (2007/10/03)
In this paper we describe the synthesis of a new series of substituted 2-(4-alkoxy or 4-acyloxyphenethyl)-phthalimide derivatives (4-11), in good yields (58-87%), exploring the remarkable fast O-alkylation or O-acylation of 2-(4-hydroxyphenethyl)-phthalimide (3) in dry media under microwave irradiation.
