6499-41-8Relevant academic research and scientific papers
Effect of intramolecular hydrogen bond on the azide-tetrazole equilibrium of 5-(2'-hydroxyphenyl)tetrazolopyrimidine, -tetrazolopyrimidine, -tetrazoloquinazoline and 7-(2'-hydroxyphenyl)tetrazolopyrimidine
Krivopalov, V. P.,Mamatyuk, V. I.,Nikolaenkova, E. B.
, p. 1435 - 1443 (1995)
The intramolecular hydrogen bond between the phenolic hydroxyl and the pyrimidine nitrogen atom in the title compounds exerts a destabilizing effect on the tetrazole ring and shifts the azide-tetrazole equilibrium toward the azide form, especially in the
Expeditious Synthesis of 2-Phenylquinazolin-4-amines via a Fe/Cu Relay-Catalyzed Domino Strategy
Jia, Feng-Cheng,Zhou, Zhi-Wen,Xu, Cheng,Cai, Qun,Li, Deng-Kui,Wu, An-Xin
supporting information, p. 4236 - 4239 (2015/09/15)
A highly efficient Fe/Cu relay-catalyzed domino protocol has been developed for the synthesis of 2-phenylquinazolin-4-amines from commercially available ortho-halogenated benzonitriles, aldehydes, and sodium azide. This elegant domino process involved con
Synthesis and anticonvulsant activity evaluation of 5-Phenyl-[1,2,4] triazolo[4,3-c]quinazolin-3-amines
Zheng, Yan,Bian, Ming,Deng, Xian-Qing,Wang, Shi-Ben,Quan, Zhe-Shan
, p. 119 - 126 (2013/03/29)
In the present study we describe the syntheses and anticonvulsant activity evaluation of 5-phenyl-[1,2,4]triazolo[4,3-c]quinazolin-3-amine derivatives. Their anticonvulsant activity and neurotoxicity were evaluated by the maximal electroshock seizure test (MES) and the rotarod test, respectively. The majority of the compounds prepared were effective in the MES screens at a dose level of 100 mg/kg. Of these compounds, the most promising was compound 8h, which showed an ED50 value of 27.4 mg/kg and a protective index (PI) value of 5.8. These values were superior to those provided by valproate (ED50 and PI values of 272 and 1.6, respectively) in the MES test in mice. As well as its anti-MES efficacy, the potencies of compound 8h against seizures induced by pentylenetetrazole and thiosemicarbazide were also established, with the results suggesting that the GABAergic system-mediated mechanisms might be involved in its anticonvulsant activity. Copyright
The Chemistry of 5-Oxodihydroisoxazoles. XIV. Synthesis of 2-(1-Aryltetrazol-5-yl)propanoic Acids
Caiazza, Daniela,Prager, Rolf H.,Schafer, Karl
, p. 1861 - 1872 (2007/10/03)
A number of N-arylisoxazol-5(2H)-ones (aryl = phenyl, isoquinolin-1-yl, quinolin-2-yl, 2-phenylquinazolin-4-yl and benzothiazol-2-yl) have been reacted with lithium azide to give 2-(1-aryltetrazol-5-yl)acetic esters, which have been C-methylated and hydrolysed.The resulting 2-(1-aryltetrazol-5-yl)propanoic acid had low antiinflammatory activity, as judged by inhibition of synthesis of prostaglandin PGE2 or tumor necrosis factor α.
SYNTHESIS OF SOME NEW CHLORO DERIVATIVES OF QUINAZOLINOQUINAZOLIN-8-ONE AND s-TETRAZOLOQUINAZOLINE WITH EXPECTED ANTIFUNGICIDAL AND ANTIBACTERIAL ACTIVITIES
Abdel-Megeed, Mohamed F.,Yassin, S. M.,El-Shanshour, A. R.,El-Badawi, M.
, p. 189 - 197 (2007/10/02)
Some derivatives of 4-chloro-2-(phenyl or 4-chlorophenyl)-1,3-quinazoline have been prepared by treating the respective 4(3H) quinazolinone derivatives with POCl3/PCl5.The products were allowed to react with anthranilic, 5-chloro and 3,5-dichloroanthranil
The Chemistry of 5-Oxodihydroisoxazoles. IV. Reactions of Some N-Arylisoxazol-5-ones with Nucleophiles
Ang, Kiah H.,Donati, Cosimo,Donkor, Augustine,Prager, Rolf H.
, p. 2037 - 2048 (2007/10/02)
The reactions of ethyl 2-aryl-5-oxo-2,5-dihydroisoxazole-4-carboxylate (aryl = phenyl, isoquinolin-1-yl, 2-phenylquinazolin-4-yl and 5-nitropyridin-2-yl) with azide and primary, secondary and tertiary amines, and a number of other nucleophiles are describ
