6499-72-5

Upstream product

• 101961-58-4 2-amino-N-phenylpropanamide 
• 6499-72-5 N¹-phenylpropane-1,2-diamine 
• 857583-43-8 N-(β-anilino-isopropyl)-benzamide 
• 108-86-1 bromobenzene 
• 78-90-0 1,2-diaminopropan 
• 591-50-4 iodobenzene 
• 33609-38-0 4-methyl-1-phenyl-2-imidazolidinone 
• 1309388-64-4 1-allyl-3-(4-methoxyphenyl)-1-phenylurea 
• 1309388-54-2 3-(4-methoxyphenyl)-4-methyl-1-phenylimidazolidin-2-one 
• 589-09-3 N-allyl-N-phenylamine 

Downstream Products

• 6499-72-5 (+)-N¹-phenyl-propylenediamine 
• 62733-57-7 2-Methyl-2-(1-methyl-2-phenylamino-ethylamino)-propionic acid ethyl ester 

Relevant academic research and scientific papers

An efficient and recyclable chitosan supported copper(II) heterogeneous catalyst for C-N cross coupling between aryl halides and aliphatic diamines

A useful and convenient methodology has been developed for synthesis of mono N-arylated aliphatic 1,2- and 1,3-diamines and amino alcohols. A highly efficient and renewable heterogeneous chitosan supported copper(II) catalyst has been employed for the C-N cross coupling between aryl halides and aliphatic diamines/amino alcohols. The main advantages of this reaction are the high yields of the products, reduced reaction time, convenient work up procedure, renewability of the catalyst, and less metal contamination of the products. All these factors make the present C-N cross coupling reaction economical, green, and sustainable.

Solvent-free copper-catalyzed N-arylation of amino alcohols and diamines with aryl halides

A simple and mild method for the coupling of aryl halides with amino alcohols and diamines is described. The reactions can be performed under ligand-free and solvent-free conditions, and generate the products in good yield.

Gold(I)-catalyzed intramolecular hydroamination of N-allylic N′-arylureas to form imidazolidin-2-ones

Treatment of N-allylic N′-arylureas with a catalytic 1:1 mixture of di-tert-butyl-o-biphenylphoshphine gold(I) chloride and silver hexafluorophosphate (1 mol%) in chloroform at room temperature led to 5-exo-hydroamination to form the corresponding imidazolidin-2-ones in excellent yield. In the case of N-allylic ureas that possessed an allylic alkyl, benzyloxymethyl, or acetoxymethyl substituent, gold(I)-catalyzed 5-exo-hydroamination leads to formation of the corresponding trans-3,4-disubstituted imidazolidin-2-ones in excellent yield with ≥50:1 diastereoselectivity.