65018-04-4

Usage

Uses

Used in Fragrance Industry:
(-)-Elema-1,3,11⁽¹³⁾-trien-12-ol is used as a scent ingredient for its distinctive woody and floral aroma, enhancing the appeal of perfumes, lotions, and soaps.
Used in Cosmetic Industry:
In the cosmetic industry, (-)-Elema-1,3,11⁽¹³⁾-trien-12-ol serves as a fragrance component, contributing to the pleasant scent of various cosmetic products.
Used in Pharmaceutical Research:
(-)-Elema-1,3,11⁽¹³⁾-trien-12-ol is used as a subject of interest in pharmaceutical research due to its potential medicinal properties, such as anti-inflammatory and antioxidant effects, which may lead to the development of new therapeutic agents.

Upstream product

• 515-13-9 β-elemene 
• 127-09-3 sodium acetate 
• 1162008-48-1 β-elemene acetate 
• 885691-35-0 monochloro β-elemene 
• 4584-28-5 (-)-elema-1,3,11⁽¹³⁾-trien-12-al 

Downstream Products

• 1438289-15-6 C₂₂H₂₉NO₂ 
• 1438289-13-4 C₂₀H₃₃NO₂ 
• 1438289-14-5 C₁₉H₃₁NO₂ 
• 1438289-16-7 C₂₂H₃₅NO₂ 
• 1438289-12-3 C₂₂H₂₈O₂ 

Relevant academic research and scientific papers

The protective effects of a novel synthetic β-elemene derivative on human umbilical vein endothelial cells against oxidative stress-induced injury: Involvement of antioxidation and PI3k/Akt/eNOS/NO signaling pathways

Antioxidant therapy is considered as promising strategy for treating oxidative stress-induced cardiovascular disease. Bis (β-elemene-13-yl) glutarate (BEG) is a novel β-elemene derivative. Herein, we examined the antioxidant activity of BEG on human umbil

Beta-elemene dipolymer derivative as well as preparation method and purpose thereof

The invention relates to the fields of natural medicines and medicinal chemistry, and particularly discloses a beta-elemene dipolymer derivative (I), (II), (III) or (IV), wherein the definitions of X, R1, R2, R3, R4, R5, R6 and Y are shown in the specific

Beta-elemene derivative containing dihydropyridine structure, and preparation method and purpose thereof

The invention relates to the field of new medicine research and development and tumor therapy, in particular to a novel beta-elemene derivative containing a dihydropyridine structure, particularly a derivative directly or indirectly introducing the brain-targeted dihydropyridine structure through a connecting arm in a beta-elemene 13 bit. The invention also discloses a preparation method of the beta-elemene derivative with the brain-targeted function, and a purpose of the novel derivative for treating gliomas.

Antioxidant Properties of Novel Dimers Derived from Natural β-Elemene through Inhibiting H2O2-Induced Apoptosis

A series of novel β-elemene dimer derivatives were synthesized and evaluated for their antioxidant activities. The results indicated that most of the target compounds showed more potent cytoprotective effects than positive control vitamin E. In particular, dimer D5 exhibited the strongest antioxidant activity, which was significantly superior to the active compound D1 obtained in our previous study. Besides, D5 did not produce obvious cytotoxicity in normal human umbilical vein endothelial cells (HUVECs) and increased the viability of HUVECs injured by H2O2 in a concentration-dependent manner. Further studies suggested that the cytoprotective action of D5 might be mediated, at least in part, by increasing the intracellular superoxide dismutase activity and nitric oxide secretion as well as decreasing the intracellular malonyldialdehyde content and lactate dehydrogenase release. Furthermore, D5 observably inhibited ROS generation and prevented H2O2-induced apoptosis in HUVECs possibly via inhibiting the activation of the MAPK signaling pathway.

Discovery of novel antitumor nitric oxide-donating β-elemene hybrids through inhibiting the PI3K/Akt pathway

A series of novel furoxan-based NO-donating β-elemene hybrids were designed and synthesized to improve the anticancer efficacy of natural β-elemene. The bioassay results indicated that all of the target compounds exhibited significantly improved antiproliferative activities against three cancer cell lines (SGC-7901, HeLa and U87) compared to parent compound β-elemene. Interestingly, these compounds displayed excellent sensitivity to U87?cells with IC50 values ranging from 173 to 2?nM. Moreover, most compounds produced high levels of NO in?vitro, and the antitumor activity of 11a in U87?cells was markedly attenuated by an NO scavenger (hemoglobin or carboxy-PTIO). Further mechanism studies revealed that 11a caused the G2 phase arrest of the cell cycle and induced apoptosis of U87?cells by preventing the activation of the PI3K/Akt pathway. Moreover, 11a significantly suppressed the tumor growth in H22 liver cancer xenograft mouse model with a tumor inhibitory ratio (TIR) of 64.8%, which was superior to that of β-elemene (TIR, 49.6%) at the same dose of 60?mg/kg. Together, the remarkable biological profiles of these novel NO-donating β-elemene derivatives may make them promising candidates for the intervention of human cancers.

Isopropanolamine substituted beta-elemene derivative and preparation method and application thereof

The invention relates to an isopropanolamine substituted beta-elemene derivative and a preparation method and an application of the isopropanolamine substituted beta-elemene derivative. Particularly, the invention relates the novel isopropanolamine substituted beta-elemene derivative shown in the general formula (I) or (II), the preparation method of the isopropanolamine substituted beta-elemene derivative, and the application of the isopropanolamine substituted beta-elemene derivative to preparation of antitumor drugs.

Synthesis, characterization, and in vitro antiproliferative activity of novel β-elemene monosubstituted derivatives

A series of β-elemene monosubstituted ester, carbamate, acylamide, and carbamidine derivatives were synthesized via intermediates, β-elemene alcohol and β-elemene amine, which were synthesized from the traditional Chinese medicine, β-elemene. The structur

Hydroxylation of sesquiterpenes by enzymes from chicory (Cichorium intybus L.) roots

A microsomal enzyme preparation of chicory roots catalyses the hydroxylation of various sesquiterpene olefins in the presence of NADPH. Most of these hydroxylations take place at an isopropenyl or isopropylidene group. The number of products obtained from any of the substrates is confined to one or, in a few cases, two sesquiterpene alcohols. In addition, the conversion of (+)-valencene into nootkatone through β-nootkatol was observed. The involvement of (+)-germacrene A hydroxylase (a cytochrome P450 enzyme) and other enzymes of sesquiterpene lactone biosynthesis in these reactions is discussed.

HIRSUTINOLIDES FROM SOUTH AFRICAN VERNONIA SPECIES

The investigation of four South African Vernonia species afforded, in addition to known compounds, six ketohirsutinolides with different oxygen functions at C-8 and C-13, respectively.Furthermore, an eremantholide was present, which was the 16-epimer of a known compound and two sesquiterpene aldehydes were isolated. - Key Word Index: Vernonia glabra var. glabra; V. poskeana var. poskeana; V. poskeana var. chlorolepis; V. neocorymbosa; Compositae; sesquiterpene lactones; hirsutinolides; sesquiterpene aldehydes.