65023-77-0Relevant articles and documents
Dimroth Rearrangement and Other Investigations on Benzofuropyrimidines
Sangapure, S. S.,Agasimundin, Y. S.
, p. 115 - 117 (2007/10/02)
Synthesis of 3-alkyl- and 3-aryl-3,4-dihydro-4-iminobenzofuropyrimidines (IV-IX) by the reaction of 3-(ethoxymethylene)amino-2-benzofurancarbonitrile (II) with alkyl- and aryl-amines, and their Dimroth type rearrangement to 4-alkyl- and 4-aryl-aminobenzofuropyrimidines (X-XIV) are described.The reactions of II with ammonia and hydrazine hydrate giving 4-aminobenzofuropyrimidine (III) and 3-amino-4-imino-3,4-dihydrobenzofuropyrimidine (XV) respectively have been investigated.Conversion of XV into s-triazolopyrimidobenzofuran (XVI) and 3-amino-2-benzofurancarbonitrile (I) into various 2-alkyl-4-alkoxybenzofuropyrimidines (XVII-XX) is also reported.