62208-67-7

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
3-Amino-1-benzofuran-2-carbonitrile is utilized as an intermediate in the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides due to its unique chemical structure and properties.
Used in Biological and Pharmacological Research:
3-AMINO-1-BENZOFURAN-2-CARBONITRILE serves as a subject of study in biological and pharmacological research for its potential anti-inflammatory and anti-cancer properties, offering insights into the development of novel therapeutic agents.
Used in Biological Imaging Applications:
3-Amino-1-benzofuran-2-carbonitrile is employed as a fluorescent probe in biological imaging, aiding researchers in visualizing cellular and molecular processes, which is crucial for advancing understanding in the life sciences.

InChI:InChI=1/C9H6N2O/c10-5-8-9(11)6-3-1-2-4-7(6)12-8/h1-4H,11H2

Upstream product

• 611-20-1 salicylonitrile 
• 107-14-2 chloroacetonitrile 
• 590-17-0 cyanomethyl bromide 
• 49615-99-8 (2-cyanophenoxy)acetonitrile 

Downstream Products

• 49679-19-8 4-Aminobenzofuro<3,2-d>pyrimidine 
• 134221-88-8 4-chloro-2-phenylbenzofuro<3,2-d>pyrimidine 
• 65023-81-6 N-phenylbenzofuro[3,2-d]pyrimidin-4-amine 
• 74988-49-1 N-Benzo[4,5]furo[3,2-d]pyrimidin-4-yl-4-methyl-benzenesulfonamide 
• 74988-43-5 3-(4-Chloro-phenyl)-3H-benzo[4,5]furo[3,2-d]pyrimidin-4-ylideneamine 
• 74988-42-4 3-Phenyl-3H-benzo[4,5]furo[3,2-d]pyrimidin-4-ylideneamine 
• 65023-84-9 benzo[4,5]furo[3,2-d]pyrimidin-4-yl-(4-chloro-phenyl)-amine 
• 65023-77-0 4-Benzylaminobenzofuro<3,2-d>pyrimidine 
• 134221-91-3 4-(2-hydroxyethylamino)-2-phenylbenzofuro<3,2-d>pyrimidine 
• 134221-94-6 5-phenyl-2,3-dihydrobenzofuro<2,3-e>imidazo<1,2-c>pyrimidine 
• 39786-40-8 4-chloro-2-methylbenzofuro<3,2-d>pyrimidine 

Relevant academic research and scientific papers

Efficient new synthesis of N-arylbenzo[b]furo[3,2-d]pyrimidin-4-amines and their benzo[b]thieno[3,2-d]pyrimidin-4-amine analogues via a microwave-assisted Dimroth rearrangement

A useful and rapid access to libraries of N-arylbenzo[b]furo[3,2-d] pyrimidin-4-amines (1) and their novel benzo[b]thieno[3,2-d]pyrimidin-4-amine analogues (2) was investigated for the first time. Title compounds were obtained via microwave-accelerated co

Syntheses of 3-acetoacetylaminobenzo[b]furan derivatives having cysteinyl leukotriene 2 receptor antagonistic activity

Novel 3-acetoacetylaminobenzo[b]furan derivatives having a modified triene system at the 3-position were synthesized starting with 3-aminobenzo[b]furans. The enol isomers, 3-[(3-hydroxybul-2-enonyl)amino]benzo[b]furans (1), of the 3-acetoacetylaminobenzo[b]furans were obtained as stable isomers owing to formation of a hydrogen bonding between the enol hydroxyl group and the amidocarbonyl group. The planarity of the C-2 substituent through the C-3 side chain suggested the existence of a modified conjugational triene system in the enol compound. Cysteinyl leukotriene 1 and 2 receptor antagonistic activities for these compounds were evaluated. 2-(4-Cyanobenzoyl or ethoxycarbonyl)-3-[(2-cyano-3-hydroxybut-2-enonyl)amino]benzo[e]furans (15g, 15o, 15u) were moderately active.

Benzothiophenes and benzofurans and antiallergic use thereof

Novel benzothiophene and benzofuran derivatives having antiallergic activity are described as well as a method of manufacture, pharmaceutical compositions, and methods of use therefor. The disclosure describes the use of derivatives for prevention of the release of mediators including histamine and leukotrienes from basophils and mast cells, and prevent respiratory burst in neutrophils providing activity useful in cardiovascular disorders as well as in antiinflammatory, psoriasis, and antimigraine treatment.