39876-88-5

Basic information

• Product Name: 4-CHLORO-BENZO[4,5]FURO[3,2-D]PYRIMIDINE
• Synonyms: 4-chlorobenzofurano[3,2-d]pyrimidine;Benzofuro[3,2-d]pyrimidine, 4-chloro-;4-Chlorobenzofuro[3,2-d]pyrimidine
• CAS NO: 39876-88-5
• Molecular Formula: C₁₀H₅ClN₂O
• Molecular Weight: 204.61
• Product Categories: Heterocycle-Pyrimidine series
• Mol File: 39876-88-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 144.0 to 148.0 °C
• Boiling Point: 344.585 °C at 760 mmHg
• Flash Point: 162.199 °C
• Appearance: /
• Density: 1.474 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.728
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.21±0.40(Predicted)
• CAS DataBase Reference: 4-CHLORO-BENZO[4,5]FURO[3,2-D]PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-BENZO[4,5]FURO[3,2-D]PYRIMIDINE(39876-88-5)
• EPA Substance Registry System: 4-CHLORO-BENZO[4,5]FURO[3,2-D]PYRIMIDINE(39876-88-5)

Safety Data

• Hazardous Substances Data: 39876-88-5(Hazardous Substances Data)

Usage

Description

4-Chloro-benzo[4,5]furo[3,2-d]pyrimidine is a chemical compound that belongs to the class of organic compounds known as furopyrimidines. These are heterocyclic compounds characterized by the fusion of a furan ring to a pyrimidine ring. The presence of a chlorine atom in the compound can affect its reactivity and potential applications. Although its exact biological functions or industrial uses are not extensively documented, it is likely utilized primarily for research purposes. Due to its chemical properties, it is essential to handle this compound with appropriate safety measures.

Uses

Used in Research Applications:
4-Chloro-benzo[4,5]furo[3,2-d]pyrimidine is used as a research chemical for [application reason], such as exploring its chemical properties, reactivity, and potential interactions with other compounds. Its unique structure and the presence of a chlorine atom make it an interesting subject for scientific investigation.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-chloro-benzo[4,5]furo[3,2-d]pyrimidine is used as a starting material or intermediate in the synthesis of more complex molecules with potential therapeutic applications. Its structure may be modified to create new drug candidates or to study its interactions with biological targets.
Used in Chemical Synthesis:
4-Chloro-benzo[4,5]furo[3,2-d]pyrimidine is used as a building block in the synthesis of various organic compounds, particularly those with potential applications in materials science, agrochemistry, or other specialized fields. Its reactivity and the presence of a chlorine atom make it a valuable component in the construction of more complex molecules.

InChI:InChI=1/C10H5ClN2O/c11-10-9-8(12-5-13-10)6-3-1-2-4-7(6)14-9/h1-5H

Upstream product

• 54802-10-7 3-aminobenzofuran-2-carboxamide 
• 34844-79-6 methyl 2-(2-cyanophenoxy)ethanoate 
• 57805-85-3 methyl 3-amino-2-benzofurancarboxylate 
• 611-20-1 salicylonitrile 
• 49615-99-8 (2-cyanophenoxy)acetonitrile 
• 68-12-2 N,N-dimethyl-formamide 
• 39786-36-2 4-oxo-3,4-dihydrobenzofuro<3,2-d>pyrimidine 

Downstream Products

• 65023-81-6 N-phenylbenzofuro[3,2-d]pyrimidin-4-amine 
• 65023-96-3 4-(4-methoxy-phenoxy)-benzo[4,5]furo[3,2-d]pyrimidine 
• 65023-90-7 4-m-tolyloxy-benzo[4,5]furo[3,2-d]pyrimidine 
• 65023-84-9 benzo[4,5]furo[3,2-d]pyrimidin-4-yl-(4-chloro-phenyl)-amine 
• 65023-80-5 benzo[4,5]furo[3,2-d]pyrimidin-4-yl-cyclohexyl-amine 
• 39786-36-2 4-oxo-3,4-dihydrobenzofuro<3,2-d>pyrimidine 
• 65024-00-2 4-Hydrazinobenzofuro<3,2-d>pyrimidine 
• 65023-92-9 4-(2-chloro-phenoxy)-benzo[4,5]furo[3,2-d]pyrimidine 
• 65023-99-6 4-(3-chloro-phenylsulfanyl)-benzo[4,5]furo[3,2-d]pyrimidine 
• 65023-93-0 4-(3-chloro-phenoxy)-benzo[4,5]furo[3,2-d]pyrimidine 
• 65023-91-8 4-p-tolyloxy-benzo[4,5]furo[3,2-d]pyrimidine 
• 65023-95-2 4-(3-methoxy-phenoxy)-benzo[4,5]furo[3,2-d]pyrimidine 
• 65023-98-5 4-(2-chloro-phenylsulfanyl)-benzo[4,5]furo[3,2-d]pyrimidine 

Relevant articles and documents

ION CHANNEL INHIBITOR COMPOUNDS FOR CANCER TREATMENT

The present invention concerns a compound of following general formula (I): where: either R is an R1 group and R′ is an -A1-Cy1 group, or R is an -A1-Cy1 group and R′ is an R1 group, R1 particularly being H or (C1-C6)alkyl group;A1 being an —NH— radical or —NH—CH2— radical;Cy1 particularly being a phenyl group,A is a fused (hetero)aromatic ring having 5 to 7 atoms, for use for treating cancer.

Tyrosine kinase inhibitors. 16. 6,5,6-Tricyclic benzothieno[3,2-d]pyrimidines and pyrimido[5,4-b]- and -[4,5- b]indoles as potent inhibitors of the epidermal growth factor receptor tyrosine kinase

Several elaborations of the fundamental anilinopyrimidine pharmacophore have been reported as potent and selective inhibitors of the epidermal growth factor receptor (EGFr) tyrosine kinase. This paper reports on a series of inhibitors whereby some 6,5-bicyclic heteroaromatic systems were fused through their C-2 and C-3 positions to this anilinopyrimidine pharmacophore. Although the resulting tricycles did not produce the enormous potency of some of the (5/6),6,6-bicyclic systems, the best of them had IC50s for the EGFr TK around 1 nM. Investigation of 4-position side chains in the indolopyrimidines confirmed that m-bromoaniline was an optimal substituent for potency. Investigation of substitution within the C-(benzo)ring of benzothienopyrimidines confirmed that introduction of an extra ring can change sharply the effects of substituents when compared to similar bicyclic nuclei, and only two substituents were found which even moderately enhanced inhibitory activity over the parent compound for this series.