65044-35-1

Usage

Uses

Used in Organic Synthesis:
Pyrrolidinium, 1-(chlorophenylmethylene)-, chloride is used as a catalyst in various organic reactions. Its ability to facilitate and enhance the efficiency of these reactions makes it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
Pyrrolidinium, 1-(chlorophenylmethylene)-, chloride is used as an intermediate in the synthesis of pharmaceutical compounds. Its role in the production of various drugs highlights its importance in the development of new and effective medications.
Used in Chemical Research:
Pyrrolidinium, 1-(chlorophenylmethylene)-, chloride is also utilized in chemical research to explore new reaction pathways and develop innovative synthetic methods. Its diverse applications in research contribute to the advancement of organic chemistry.

Upstream product

• 3389-54-6 n-benzoylpyrrolidine 
• 98-88-4 benzoyl chloride 

Downstream Products

• 79298-06-9 methyl 4,6-O-benzylidene-2,3-di-O-thiobenzoyl-α-D-glucopyranoside 
• 91245-77-1 1-benzylpyrrolidine hydrochloride 
• 15563-45-8 1-thiobenzoylpyrrolidine 

Relevant academic research and scientific papers

Frustrated Lewis Pair Catalyzed Hydrogenation of Amides: Halides as Active Lewis Base in the Metal-Free Hydrogen Activation

A method for the metal-free reduction of carboxylic amides using oxalyl chloride as an activating agent and hydrogen as the final reductant is introduced. The reaction proceeds via the hydrogen splitting by B(2,6-F2-C6H3)3 in combination with chloride as the Lewis base. Density functional theory calculations support the unprecedented role of halides as active Lewis base components in the frustrated Lewis pair mediated hydrogen activation. The reaction displays broad substrate scope for tertiary benzoic acid amides and α-branched carboxamides.

Conversion of Amides and Lactams to Thioamides and Thiolactams Using Hexamethyldisilathiane

Amides and lactams were converted to their corresponding thioamides and thiolactams employing a new protocol using hexamethyldisilathiane (TMS2S).Oxophilic promoters were employed to generate Vilsmeier-type intermediates, the most efficient reagents being phosphorus oxychloride, triphosgene, and oxalyl chloride.Thionation of intermediate chloro iminium ions was accomplished in situ with TMS2S.Yields were good to excellent for secondary and tertiary amides and lactams while yields for primary systems were poor.

Reactions of Relevance to the Chemistry of Aminoglycoside Antibiotics. Part 13. A Novel Synthesis of Benzyl Ethers

Benzyl ethers were prepared from alcohols by reaction with chloro(phenylmethyl)dimethylammonium chloride and sodium hydrogen telluride in sequence.The salt (1) 1)OR2Cl-; R1=H, R2=cholest-5-en-3β-yl> and sodium borohydride gave the borane complex of 3β-dimethylaminomethoxycholest-5-ene.Salt (1; R1=Ph, R2=cholest-5-en-3β-yl or 5α-cholestan-3β-yl) and ammonia or hydrazine gave the steroidal benzimidates or benzhydrazonate.