91245-77-1Relevant academic research and scientific papers
Aluminium complex as an efficient catalyst for the chemo-selective reduction of amides to amines
Das, Suman,Karmakar, Himadri,Bhattacharjee, Jayeeta,Panda, Tarun K.
, p. 11978 - 11984 (2019/08/13)
We report an efficient protocol for the catalytic chemo-selective reduction of tert-amides with pinacolborane (HBpin) to afford the corresponding amines in high yields using aluminium complexes [κ2-{Ph2P(X)NC9H6N}Al(Me)2] [X = S (2a), Se (2b)] as pre-catalysts at room temperature. The aluminium complexes were prepared from the reaction of [Ph2P(X)NC9H6N] [X = S (1a), Se (1b)] and trimethylaluminium in toluene. The solid-state structure of complex 2b is established. Tertiary amides with a wide array of electron-withdrawing and electron-donating functional groups were easily converted to the desired products through the selective cleavage of the amides' CO bond by aluminium hydride as an active species. A kinetic study of the catalytic reaction is also reported.
Frustrated Lewis Pair Catalyzed Hydrogenation of Amides: Halides as Active Lewis Base in the Metal-Free Hydrogen Activation
Sitte, Nikolai A.,Bursch, Markus,Grimme, Stefan,Paradies, Jan
, p. 159 - 162 (2019/01/04)
A method for the metal-free reduction of carboxylic amides using oxalyl chloride as an activating agent and hydrogen as the final reductant is introduced. The reaction proceeds via the hydrogen splitting by B(2,6-F2-C6H3)3 in combination with chloride as the Lewis base. Density functional theory calculations support the unprecedented role of halides as active Lewis base components in the frustrated Lewis pair mediated hydrogen activation. The reaction displays broad substrate scope for tertiary benzoic acid amides and α-branched carboxamides.
METHOD FOR SYNTHESIZING AMMONIUM SALT AND COMPOSITION OBTAINED BY INCORPORATING POLYSACCHARIDES INTO AMMONIUM SALT
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Paragraph 0031, (2016/12/22)
PROBLEM TO BE SOLVED: To provide a method for synthesizing an ammonium salt containing a quaternary ammonium salt in a shorter time than a conventionally known example and to provide a new composition containing an ammonium salt and polysaccharides such as cellulose or chitin. SOLUTION: There are provided: a method for synthesizing ammonium salt containing a quaternary ammonium salt in a shorter time than a conventionally known example; and a method for producing a new composition containing an ammonium salt and polysaccharides such as cellulose or chitin. COPYRIGHT: (C)2015,JPOandINPIT
Acid promoted cyclodehydration of amino alcohols with amide acetal
Hwang, Soonho,Park, Heemin,Kwon, Yongseok,Kim, Sanghee
, p. 60017 - 60024 (2015/02/19)
A convenient acid-promoted cyclization protocol for the formation of azaheterocycles from amino alcohols is described. The reaction involves the use of N,N-dimethylacetamide dimethyl acetal (DMADA) as the activating reagent of the hydroxyl group. Using this protocol, pyrrolidines or piperidines with various substituents can be synthesized in good to high yields.
