65051-18-5Relevant academic research and scientific papers
Design and synthesis of novel substituted indole-acrylamide derivatives and evaluation of their anti-cancer activity as potential tubulin-targeting agents
Baytas, Sultan Nacak,Cetin-Atalay, Rengul,Ergun, Sezen Guntekin,Hamel, Ernest,Hawash, Mohammed,Kahraman, Deniz Cansen,Olgac, Abdurrahman
, (2022/01/19)
Novel compounds containing polar and nonpolar substitutions on the prop-2-en-1-on linker of the trans-indol-3-ylacrylamide scaffold were designed by modeling within the colchicine site of tubulin and then synthesized to determine the role of such substitu
Malonic ester amide synthesis: An efficient methodology for synthesis of amides
Mahajan, Pankaj S.,Mahajan, Jyoti P.,Mhaske, Santosh B.
, p. 2508 - 2516 (2013/07/25)
A general methodology malonic ester amide synthesis has been demonstrated, which uses α-substituted/unsubstituted diethyl malonates for the decarboxylative acylation of various aromatic/heteroaromatic primary/secondary amines to form one-carbon homologated amides, thus providing easy access to amides with odd/even chain lengths and an array of substituents on the alkyl/aryl part while avoiding use of acyl chlorides or peptide coupling reagents. Copyright
