65055-37-0Relevant academic research and scientific papers
PROCESS FOR PREPARING UNSYMMETRIC SECONDARY TERT-BUTYLAMINES IN THE LIQUID PHASE
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Page/Page column 6, (2011/10/19)
The present application relates to a process for preparing unsymmetric secondary tert-butylamines which, as well as the tert-butyl radical, also comprise an alkyl, cycloalkyl or benzyl radical. They are prepared by reacting corresponding aldehydes with tert-butylamine and hydrogen in the presence of hydrogenation catalysts (reductive amination) in the liquid phase.
Transfer hydrogenation of imines with ammonia-borane: A concerted double-hydrogen-transfer reaction
Yang, Xianghua,Zhao, Lili,Fox, Thomas,Wang, Zhi-Xiang,Berke, Heinz
supporting information; experimental part, p. 2058 - 2062 (2010/06/20)
(Chemical Equation Presented) Direct transfer hydrogenation of imines was observed with ammonia-borane, which proceeded under mild conditions without the help of a catalyst. The results of deuterium kinetic isotope effects, Hammett correlations, and DFT calculations all support a concerted double-hydrogen- transfer mechanism (see scheme).
The synthesis of baclofen and GABOB via Rh(II) catalyzed intramolecular C-H insertion of α-diazoacetamides
Chen, Zhenliang,Chen, Zhiyong,Jiang, Yaozhong,Hu, Wenhao
, p. 1579 - 1586 (2007/10/03)
The synthesis of baclofen and GABOB is reported via hydrolysis of the corresponding N-tert-butyl γ-lactams, which were obtained from Rh(II) catalyzed intramolecular C-H insertion of α-diazoacetamides.
Synthesis of enantiomerically pure C2-symmetric acyclic and cyclic 1,2-diamines via pinacol coupling of imines
Annunziata, Rita,Benaglia, Maurizio,Caporale, Marinella,Raimondi, Laura
, p. 2727 - 2734 (2007/10/03)
The inter- and intramolecular coupling of imines promoted by samarium diiodide and Lewis acids or by Zn/MsOH was extensively studied. The intramolecular reaction of chiral, enantiomerically pure bis-imines was also considered, and allowed the efficient, s
Reductive amination of aldehydes and ketones with sodium triacetoxyborohydride. Studies on direct and indirect reductive amination procedures
Abdel-Magid, Ahmed F.,Carson, Kenneth G.,Harris, Bruce D.,Maryanoff, Cynthia A.,Shah, Rekha D.
, p. 3849 - 3862 (2007/10/03)
Sodium triacetoxyborohydride is presented as a general reducing agent for the reductive amination of aldehydes and ketones. Procedures for using this mild and selective reagent have been developed for a wide variety of substrates. The scope of the reaction includes aliphatic acyclic and cyclic ketones, aliphatic and aromatic aldehydes, and primary and secondary amines including a variety of weakly basic and nonbasic amines. Limitations include reactions with aromatic and unsaturated ketones and some sterically hindered ketones and amines. 1,2-Dichloroethane (DCE) is the preferred reaction solvent, but reactions can also be carried out in tetrahydrofuran (THF) and occasionally in acetonitrile. Acetic acid may be used as catalyst with ketone reactions, but it is generally not needed with aldehydes. The procedure is carried out effectively in the presence of acid sensitive functional groups such as acetals and ketals; it can also be carried out in the presence of reducible functional groups such as C-C multiple bonds and cyano and nitro groups. Reactions are generally faster in DCE than in THF, and in both solvents, reactions are faster in the presence of AcOH. In comparison with other reductive amination procedures such as NaBH3CN/MeOH, borane-pyridine, and catalytic hydrogenation, NaBH(OAc)3 gave consistently higher yields and fewer side products. In the reductive amination of some aldehydes with primary amines where dialkylation is a problem we adopted a stepwise procedure involving imine formation in MeOH followed by reduction with NaBH4.
