650633-85-5Relevant academic research and scientific papers
Cross-dehydrogenative coupling strategy for phosphonation and cyanation of secondary N-alkyl anilines by employing 2,3-dichloro-5,6-dicyanobenzoquinone
Liu, Qing,Yu, Shuchen,Hu, Liangzhen,Hussain, Muhamad Ijaz,Zhang, Xiaohui,Xiong, Yan
, p. 7209 - 7217 (2018/11/10)
The cross-dehydrogenative coupling strategy for metal-free phosphonation and cyanation of secondary N-alkyl anilines has been developed firstly under mild reaction conditions. Based on detailed optimization of reaction conditions, the substrate generality of N-alkyl anilines and various hydrogen phosphonates has been investigated, and a series of versatile α-aminophosphonates and α-aminonitriles were therefore furnished in good to excellent yields. A plausible collective reaction mechanism through dehydrogenation to imine formation, then to respective α-aminophosphonates and α-aminonitriles was proposed.
Aminophosphonates as novel anti-leishmanial chemotypes: Synthesis, biological evaluation, and CoMFA studies
Bhagat, Srikant,Shah, Parth,Garg, Sanjeev K.,Mishra, Shweta,Kamal Kaur, Preet,Singh, Sushma,Chakraborti, Asit K.
supporting information, p. 665 - 670 (2014/05/06)
A series of twenty six structurally diverse α-aminophosphonates have been synthesized and evaluated for in vitro anti-leishmanial activity and cytotoxicity using the MTT assay. Among them, seven compounds (1-7) exhibited anti-leishmanial potency against t
P-Dodecylbenzenesulfonic acid: A highly efficient catalyst for one-pot synthesis of α-aminophosphonates in aqueous media
Movassagh, Barahman,Alapour, Saba
, p. 174 - 178 (2013/06/27)
A highly efficient one-pot three-component reaction of aldehydes or ketones, amines, and trimethyl or triethyl phosphite catalyzed by p-dodecylbenzensulfonic acid is developed for the synthesis of α-aminophosphonates at room temperature in water.
Zirconium(IV) compounds as efficient catalysts for synthesis of α-aminophosphonates
Bhagat, Srikant,Chakraborti, Asit K.
, p. 6029 - 6032 (2008/12/21)
(Chemical Equation Presented) Zirconium(IV) compounds are reported as excellent catalysts for a three-component one-pot reaction of an amine, an aldehyde or a ketone, and a di/trialkyl/aryl phosphite to form α-aminophosphonates under solvent-free conditions at rt. Among the various zirconium compounds, ZrOCl2?8H2O and ZrO(ClO 4)2?6H2O were most effective. The reactions were faster with dialkyl/diaryl phosphites than with trialkyl/triaryl phosphites. No O-Me cleavage occurs with aryl methyl ether and methyl ester groups. α/β-Unsaturated carbonyl moiety does not undergo conjugate addition with the phorphorous moiety.
