Welcome to LookChem.com Sign In|Join Free

CAS

  • or

65068-86-2

Post Buying Request

65068-86-2 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

65068-86-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 65068-86-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,0,6 and 8 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 65068-86:
(7*6)+(6*5)+(5*0)+(4*6)+(3*8)+(2*8)+(1*6)=142
142 % 10 = 2
So 65068-86-2 is a valid CAS Registry Number.

65068-86-2Relevant articles and documents

Design, synthesis, and molecular docking study of new tyrosyl-dna phosphodiesterase 1 (Tdp1) inhibitors combining resin acids and adamantane moieties

Kovaleva, Kseniya,Yarovaya, Olga,Ponomarev, Konstantin,Cheresiz, Sergey,Azimirad, Amirhossein,Chernyshova, Irina,Zakharenko, Alexandra,Konev, Vasily,Khlebnikova, Tatiana,Mozhaytsev, Evgenii,Suslov, Evgenii,Nilov, Dmitry,?vedas, Vytas,Pokrovsky, Andrey,Lavrik, Olga,Salakhutdinov, Nariman

, (2021/05/22)

In this paper, a series of novel abietyl and dehydroabietyl ureas, thioureas, amides, and thioamides bearing adamantane moieties were designed, synthesized, and evaluated for their in-hibitory activities against tyrosil-DNA-phosphodiesterase 1 (TDP1). The synthesized compounds were able to inhibit TDP1 at micromolar concentrations (0.19–2.3 μM) and demonstrated low cytotox-icity in the T98G glioma cell line. The effect of the terpene fragment, the linker structure, and the adamantane residue on the biological properties of the new compounds was investigated. Based on molecular docking results, we suppose that adamantane derivatives of resin acids bind to the TDP1 covalent intermediate, forming a hydrogen bond with Ser463 and hydrophobic contacts with the Phe259 and Trp590 residues and the oligonucleotide fragment of the substrate.

Synthesis of Homologs of 1-Isothiocyanatoadamantane

Pitushkin,Burmistrov,Butov

, p. 1475 - 1479 (2019/01/04)

Amines of the adamantane series reacted with carbon disulfide and di-tert-butyl dicarbonate in the presence of triethylamine and a catalytic amount of 4-(dimethylamino)pyridine to give homologs of 1-isothiocyanatoadamantane in 80–86% yields. Adamantan-2-a

Nitrogen heterocyclic carboximidamide compounds

-

, (2008/06/13)

5-, 6- or 7-Membered fully saturated 1-azacarbocyclic-2-ylidene derivatives of guanidine having anti-secretory and hypoglycemic activities, and further useful for treatment of cardiovascular disease states.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 65068-86-2