65069-76-3

Upstream product

• 1736-70-5 3-trifluoromethylphenylthiourea 
• 74-88-4 methyl iodide 
• 98-16-8 3-trifluoromethylaniline 
• 1840-19-3 1-isothiocyanato-3-trifluoromethyl-benzene 

Downstream Products

• 77391-33-4 N-(3-Trifluoromethyl-phenyl)-morpholine-4-carboxamidine; hydriodide 
• 65070-04-4 C₁₄H₁₈F₃N₃ 
• 1269603-82-8 (4S)-4-(N-benzyloxycarbonyl-2-aminoethyl)-2-[(3-trifluoromethylphenyl)amino]imidazoline 
• 1269487-77-5 (4S)-4-(N-benzyloxycarbonyl-2-aminoethyl)-2-[(3-trifluoromethylphenyl)amino]imidazoline hydrochloride 
• 1321594-46-0 C₁₉H₁₄F₃N₇O 
• 877874-85-6 KG₅ 
• 877874-79-8 4-[5-(3-trifluoromethyl-phenylamino)-4H-[1,2,4]triazol-3-yl]-phenol 

Relevant academic research and scientific papers

Heterocyclic compounds useful for kinase inhibition

Provided herein are compounds useful for kinase inhibition.

New imidazoline/α2-adrenoceptors affecting compounds-4(5)-(2-aminoethyl)imidazoline (dihydrohistamine) derivatives. Synthesis and receptor affinity studies

Compilation of agmatine structure and imidazoline moiety leads to a new group of imidazoline/α2-adrenoceptor ligands, 4(5)-(2-aminoethyl)imidazoline derivatives. In this study the exploration of previously unknown 4(5)-(2-aminoethyl)imidazolines including the analogues of reported imidazoline and α2-aderenoceptors ligands: clonidine, rilmenidine, idazoxan, efaroxan, antazoline, tracizoline is described. The synthesis of a variety of novel 4(5)-(2-aminoethyl)imidazolines and their I 1, I2, α2-adrenoceptors affinities are reported.

THERAPEUTIC METHODS AND COMPOSITIONS INVOLVING ALLOSTERIC KINASE INHIBITION

The present invention is directed to methods and compositions for suppressing lymphangiogenesis, angiogenesis and/or tumor growth. The methods comprise contacting the tumor with a compound that (i) stabilizes a protein kinase in the inactive state and (ii

HETEROCYCLIC COMPOUNDS AND METHODS OF USE

Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.

A Versatile Synthesis of Novel N,N,N''-Trisubstituted Guanidines

N,N,N''-Trisubstituted guanidines (most of them N''-aryl-N-azacycloalkanecarboximidamides) are prepared in generally good yields by S-methylation of monosubstituted thioureas with methyl iodide in methanol or acetone and reaction of the resultant methyl c

Guanidines, pharmaceutical compositions and use

The invention relates to novel guanidine derivatives, particularly to substituted guanidines of the formula STR1 having hypoglycaemic activity, for the oral treatment of hyperglycaemia in mammals, especially for the oral treatment of Diabetes mellitus.