65078-63-9

Upstream product

• 132934-85-1 5-Acetyl-3-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-[1,3,4]thiadiazin-6-one 
• 132934-88-4 5-Acetyl-3-(4-methoxy-phenyl)-2-[(Z)-phenylimino]-2,3-dihydro-[1,3,4]thiadiazin-6-one 
• 4346-59-2 para-methoxyphenyldiazonium chloride 
• 108-26-9 3-methyl-2-pyrazoline-5-one 
• 18794-95-1 3-oxo-2-(2-(4-methoxyphenyl)hydrazono)butanoic acid ethyl ester 

Downstream Products

• 1415650-72-4 4-[2-(4-methoxyphenyl)hydrazono]-3-methyl-1-(prop-2-ynyl)-1H-pyrazol-5(4H)-one 
• 1415650-77-9 1-allyl-4-[2-(4-methoxyphenyl)hydrazono]-3-methyl-1H-pyrazol-5(4H)-one 
• 1415650-80-4 4-[2-(4-methoxyphenyl)hydrazono]-3-methyl-1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-1H-pyrazol-5(4H)-one 

Relevant academic research and scientific papers

Synthesis and antimicrobial evaluation of novel pyrazolones and pyrazolone nucleosides

The synthesis of a novel series of 4-Arylhydrazono-5-methyl-1,2- dihydropyrazol-3-ones 4a-h, and their N 2-Alkyl and acyclo, glucopyranosyl, and ribofuranosyl derivatives is described. K2CO 3 catalyzed alkylation of 4a-h with allyl bromide, propargyl bromide, 4-bromobutyl acetate, 2-Acetoxyethoxymethyl bromide, and 2,3,4,6-tetra-O- Acetyl-D-glucopyranosyl bromide proceeded selectively at the N 2-position of the pyrazolinone ring. Glycosylation of 4a with 1,2,3,5-tetra-O-Acetyl-D-ribofuranose under Vorbruggen glycosylation conditions gave the corresponding N 2-4-Arylhydrazonopyrazolone ribofuranoside 9a in good yield. Conventional deprotection of the acetyl protected nucleosides furnished the corresponding 4-Arylhydrazonopyrazolone nucleosides in good yields. Selected numbers of the newly synthesized compounds were screened for antimicrobial activity. Compounds 4b, 12a, and 14d showed moderate activities against Aspergillus flavus, Penicillium sp., and Escherichia coli.

Synthesis of novel mannich bases containing pyrazolones and indole systems

Novel mannich bases 7 a-h were synthesized the condensation reaction between 3-Methyl-5-oxo-4-(4'phenyl hydrazono)-4,5-dihydro-pyrazol-1-yl]-acetic acid hydrazide 4 With Isatin yielded the corresponding [3-Methyl5-oxo-4-(4'- substitutedarylhydrazono)-4,5-dihydro-pyrazol-l-yl]-aceticacid(2-oxo-l, 2-dihydro-indol-3-ylidene)hydrazide 6, this was subjected to mannich reaction with cyclic secondary amines in the presence of formaldehyde in DMF to give corresponding hydrazide 7 in excellent yields. The structures of these newly synthesized compounds were characterized by 1H-NMR, Mass, IR and elemental analysis.