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Usage

Uses

Used in Pharmaceutical Industry:
PERFLUORO-P-XYLENE is used as a building block for synthesizing organofluorine compounds, which are essential in the development of pharmaceuticals. Its high reactivity with active hydrogen-containing substances allows for the creation of various complex molecules with potential therapeutic applications.
Used in Specialty Polymers Production:
PERFLUORO-P-XYLENE is used as an intermediate in the synthesis of specialty polymers, which are materials with unique properties that can be tailored for specific applications. These polymers can be used in various industries, such as electronics, automotive, and aerospace, due to their enhanced performance characteristics.
Used in Agricultural Chemicals Production:
PERFLUORO-P-XYLENE is used as a key component in the production of agricultural chemicals, which are essential for crop protection and enhancement of agricultural productivity. Its involvement in the synthesis of these chemicals contributes to the development of more effective and environmentally friendly agrochemicals.
Used in Surface-Active Fluorinated Substances Production:
PERFLUORO-P-XYLENE is used as a precursor in the production of surface-active fluorinated substances, which are compounds with unique properties that can lower surface tension and improve the performance of various products, such as lubricants, surfactants, and coatings.
Safety Precautions:
Handling PERFLUORO-P-XYLENE requires caution as it can cause eye and skin irritation. Prolonged exposure may lead to more serious health hazards, and therefore, appropriate safety measures should be taken to minimize risks during its use and production.

InChI:InChI=1/C8F10/c9-3-1(7(13,14)15)4(10)6(12)2(5(3)11)8(16,17)18

Upstream product

• 374-77-6 perfluoro-1,4-dimethylcyclohexane 
• 652-36-8 2,3,5,6-tetrafluoroterephthalic acid 
• 106-42-3 para-xylene 
• 434-64-0 perfluorotoluene 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 392-56-3 Hexafluorobenzene 
• 361-01-3 1,2,4,5-tetrachloro-3,6-bis-trifluoromethyl-benzene 

Downstream Products

• 10534-38-0 1,4-Bistrifluoromethylhexafluorocyclohexa-1,4-diene 
• 13047-67-1 1,4-Bis-trifluormethyl-hexafluor-cyclohexadien-1,3 
• 63812-16-8 piperidinium fluoride 
• 2063-33-4 2,4,5-Trifluor-3,6-bis-trifluormethyl-anisol 
• 652-36-8 2,3,5,6-tetrafluoroterephthalic acid 
• 5216-22-8 perfluoro-4-methylbenzoic acid 
• 136264-70-5 p-(trichloromethyl)heptafluorotoluene 
• 136264-72-7 p-bis(trichloromethyl)tetrafluorobenzene 
• 1840-84-2 Tetrakis-phenylmercpato-1,4-bis-trifluormethyl-benzol 
• 2062-18-2 2,5-Difluor-3,6-bis-trifluormethyl-p-xylol 
• 1997-57-5 2,4,5-Trifluor-3,6-bis-trifluormethyltoluol 
• 2062-19-3 2,5-Difluor-1,4-dimethoxy-3,6-bis-trifluormethyl-benzol 
• 2355-97-7 1,4-Difluor-2,5-bis-trifluormethyl-benzol 
• 2967-51-3 2,5-bis(trifluoromethyl)-3,4,6-trifluorobenzenethiol 

Relevant academic research and scientific papers

A Key Intermediate in Copper-Mediated Arene Trifluoromethylation, [nBu4N][Cu(Ar)(CF3)3]: Synthesis, Characterization, and C(sp2)?CF3 Reductive Elimination

The synthesis, characterization, and C(sp2)?CF3 reductive elimination of stable aryl[tris(trifluoromethyl)]cuprate(III) complexes [nBu4N][Cu(Ar)(CF3)3] are described. Mechanistic investigations, including kinetic studies, studies of the effect of temperature, solvent, and the para substituent of the aryl group, as well as DFT calculations, suggest that the C(sp2)?CF3 reductive elimination proceeds through a concerted carbon–carbon bond-forming pathway.

Borazine-CF3? Adducts for Rapid, Room Temperature, and Broad Scope Trifluoromethylation

A fluoroform-derived borazine CF3? transfer reagent is used to effect rapid nucleophilic reactions in the absence of additives, within minutes at 25 °C. Inorganic electrophiles spanning seven groups of the periodic table can be trifluoromethylated in high yield, including transition metals used for catalytic trifluoromethylation. Organic electrophiles included (hetero)arenes, enabling C?H and C?X trifluoromethylation reactions. Mechanistic analysis supports a dissociative mechanism for CF3? transfer, and cation modification afforded a reagent with enhanced stability.

Selective mono-and diamination of polyfluorinated benzenes and pyridines with liquid ammonia

Amination of pentafluoropyridine, 2,3,5,6-tetrafluoropyridine, 4-chlorotetrafluoropyridine, 3,5-dichlorotrifluoropyridine, octafluorotoluene, α,α,α,2,3,5,6-heptafluorotoluene, decafluoro-m-xylene, decafluorobiphenyl, hexafluorobenzene, and pentafluorobenzene with liquid ammonia was investigated. Bis-aminodefluorination temperatures for the majority of substrates were shown to exceed significantly the corresponding temperatures of monoaminodefluorination. The optimal conditions for selective preparation of mono-and diaminopolyfluoro(het)arenes were elucidated. An efficient method for isolation of particular polyfluorophenylenediamines from product mixtures formed in nonselective reactions of pentafluorobenzene and hexafluorobenzene with aqueous ammonia based on complexation with a crown ether is proposed.

FLUORINATIONS WITH COMPLEX METAL FLUORIDES. PART 9. FLUORINATIONS OF TOLUENE AND XYLENE DERIVATIVES BY MEANS OF CAESIUM TETRAFLUOROCOBALTATE(III)

Benzotrifluoride at 320 deg C afforded some m-fluorobenzotrifluoride and octafluorotoluene (III), together with perfluoromethylcyclohexane (I), and also traces of 2H-heptafluorotoluene and 1-trifluoromethylnonafluorocyclohex-1-ene.Toluene itself gave (difluoromethyl)benzene, fluoro- and difluoro-methylpentafluorobenzene, difluoromethylundecafluorocyclohexane and (I); also traces of di- and tri-fluoromethylnonafluorocyclohex-1-ene: no benzotrifluoride or (III) were detected. 1,3-Bis(trifluoromethyl)benzene at 420 deg C gave 4,5,6-trifluoro-1,3-bis(trifluoromethyl)benzene, decafluoro-1,3-dimethylbenzene, and perfluoro-1,3-dimethylcyclohexane.Para-xylene at 350 deg C afforded 1,4-bis(difluoromethyl)tetrafluorobenzene, 1-difluoromethyl-4-trifluoromethyltetrafluorobenzene, decafluoro-1,4-dimethylbenzene (XIX), and perfluoro-1,4-dimethylcyclohexane (XVIII).Defluorination occurred to a significant extent on passage of the saturated cyclic fluorocarbons (I) and (XVIII) over the fully spent fluorinating agent (presumably caesium trifluorocobaltate) at ca. 400 deg C; the fluorocarbon arenes, (III) and (XIX) respectively, were obtained.