651035-84-6

Usage

Uses

Used in Pharmaceutical Industry:
Methyl N-Boc-3-chloro-L-alaninate is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its enantiomerically pure nature ensures the production of high-quality, single-enantiomer drugs, which is crucial for the desired biological activity and to avoid potential side effects associated with the presence of the wrong enantiomer.
Used in Bioactive Molecule Synthesis:
In the field of bioactive molecule synthesis, Methyl N-Boc-3-chloro-L-alaninate serves as a versatile building block for creating novel compounds with potential applications in various therapeutic areas. Its unique structure allows for the development of molecules with specific biological activities, such as antimicrobial, antiviral, or anticancer properties.
Used in Research and Development:
Methyl N-Boc-3-chloro-L-alaninate is also used in research and development for the study of amino acid derivatives and their role in various biological processes. Its enantiomerically pure nature makes it an ideal candidate for investigating the effects of chirality on the biological activity of amino acid derivatives and their potential applications in drug discovery.

InChI:InChI=1/C9H16ClNO4/c1-9(2,3)15-8(13)11-6(5-10)7(12)14-4/h6H,5H2,1-4H3,(H,11,13)/t6-/m0/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 17136-54-8 Methyl (2R)-2-amino-3-chloropropionate hydrochloride 
• 2766-43-0 N-tert-butyloxycarbonyl-L-serine methyl ester 

Downstream Products

• 190834-02-7 N-(tert-butoxycarbonyl)-S-(4-hydroxy-3,5-di-tert-butylphenyl)-Cys-OCH₃ 
• 651036-27-0 [2-(1-hydroxy-cyclohexyl)-1-(S)-(2-trimethylsilanyl-ethoxymethoxymethyl)-ethyl]-carbamic acid tert-butyl ester 
• 682774-31-8 [1-(S)-2-(4-nitrophenyl)-1-(2-trimethylsilanylethoxymethoxymethyl)ethyl]carbamic acid tert-butyl ester 
• 651036-62-3 [3-oxo-3-phenyl-1-(S)-(2-trimethylsilanyl-ethoxymethoxymethyl)-propyl]-carbamic acid tert-butyl ester 
• 682774-41-0 [1-(S)-2-phenyl-1-(2-trimethylsilanylethoxymethoxymethyl)ethyl]carbamic acid tert-butyl ester 
• 651036-32-7 [2-(1-hydroxy-cyclohexyl)-1-(S)-hydroxymethylethyl]-carbamic acid tert-butyl ester 
• 651036-55-4 (3-hydroxy-1-(S)-hydroxymethyl-3-phenylpropyl)-carbamic acid tert-butyl ester 
• 246040-05-1 2-tert-butoxycarbonylamino-4-oxo-4-phenyl-butyric acid 
• 172479-51-5 (2S)-2-tert-butoxycarbonylamino-4-oxo-4-phenylbutyric acid methyl ester 
• 104227-71-6 N-[(3S)-tetrahydro-5-oxo-3-furanyl]carbamic acid-1,1-dimethylethyl ester 
• 1159501-66-2 (R)-2-tert-butoxycarbonylamino-3-(diethoxyphosphoryl)propionic acid 

Relevant academic research and scientific papers

SULFONAMIDES AS HIV PROTEASE INHIBITORS

Compounds of Formula I are disclosed: wherein L, A, R1, R2, R3A, R3B, R4A, R4B, R5, R6 and R7 are defined herein. The compounds encompassed by Formula I include compounds which are HIV protease inhibitors and other compounds which can be metabolized in vivo to HW protease inhibitors. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines

CYSTEINE PROTEASE INHIBITORS

Compounds of the formula (I) wherein R1a is H; and R1b is C1-C6alkyl, Carbocyclyl or Het; or R1a and R1b together define a saturated cyclic amine with 3-6 ring atoms; R2a and Rs

Highly functionalised organolithium and organoboron reagents for the preparation of enantiomerically pure α-amino acids

Homochiral, highly functionalised organolithium reagents derived from l-serine have been generated and reacted with electrophiles. The novel enantiomerically pure adducts thus obtained were then converted, through β-amino alcohols, into novel non-proteinogenic α-amino acids. The methodology also made available a novel boronic acid which was then employed as a Suzuki cross-coupling partner, elaborating a new pathway to phenylalanine analogues.

Highly Functionalized Organolithium Reagents for Enantiomerically Pure α-Amino Acid Synthesis

(Equation presented) Highly functionalized L-serine-derived organolithium reagents have been generated and reacted with a variety of electrophiles, delivering novel enantiomerically pure adducts. These adducts were then converted into homochiral amino alcohols and novel nonproteinogenic α-amino acids, including an aspartic acid mimic that has been synthesized in an enantiomerically pure form for the first time.

Dual inhibition of human leukocyte elastase and lipid peroxidation: In vitro and in vivo activities of azabicyclo[2.2.2]octane and perhydroindole derivatives

A series of potent and selective human leukocyte elastase (HLE) inhibitors of the Val-Pro-Val type has been developed. Initially, the central proline residue was replaced by nonnatural amino acids Phi ((2S,3aS,7aS)- perhydroindole-2-carboxylic acid) and A