651057-01-1

Basic information

• Product Name: 1-(METHYLSULFONYL)PIPERIDIN-4-AMINE HYDROCHLORIDE
• Synonyms: 1-(METHYLSULFONYL)PIPERIDIN-4-AMINE HYDROCHLORIDE;1-METHANESULFONYL-PIPERIDIN-4-YLAMINE HYDROCHLORIDE;1-Methanesulfonylpiperidin-4-aMine hydrochloride;4-AMino-1-(Methanesulfonyl)piperidine hydrochloride;1-(Methylsulfonyl)-4-piperidinaMine HCl
• CAS NO: 651057-01-1
• Molecular Formula: C6H15ClN2O2S
• Molecular Weight: 214.7135
• Mol File: 651057-01-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 328.3 °C at 760 mmHg
• Flash Point: 152.3 °C
• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(METHYLSULFONYL)PIPERIDIN-4-AMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(METHYLSULFONYL)PIPERIDIN-4-AMINE HYDROCHLORIDE(651057-01-1)
• EPA Substance Registry System: 1-(METHYLSULFONYL)PIPERIDIN-4-AMINE HYDROCHLORIDE(651057-01-1)

Safety Data

• Safety Statements: 24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 651057-01-1(Hazardous Substances Data)

Usage

General Description

1-(Methylsulfonyl)piperidin-4-amine hydrochloride is a chemical compound that is commonly used as a intermediate in the synthesis of various pharmaceuticals and organic compounds. It is a derivative of piperidine and contains a methylsulfonyl group, making it a popular reagent in organic chemistry. The hydrochloride salt form of this compound allows for easier handling and storage, while also increasing its solubility in water, making it more suitable for certain chemical reactions. This chemical is primarily used in the pharmaceutical industry for the synthesis of various drugs, and it may also have other industrial applications.

InChI:InChI=1S/C6H14N2O2S.ClH/c1-11(9,10)8-4-2-6(7)3-5-8;/h6H,2-5,7H2,1H3;1H

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 73874-95-0 (piperidin-4-yl)carbamic acid tert-butyl ester 
• 287953-38-2 (1-methanesulfonyl-piperidin-4-yl)carbamic acid tert-butyl ester 

Downstream Products

• 1190043-78-7 4-(cyclopropylmethoxy)-N-[8-methyl-3-({[1-(methylsulfonyl)piperidin-4-yl]amino}methyl)quinolin-7-yl]benzamide 

Relevant articles and documents

Synthesis and biological evaluation of ethacrynic acid derivatives bearing sulfonamides as potent anti-cancer agents

A series of ethacrynic acid (2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid) (EA, Edecrin) containing sulfonamides linked via three types of linkers namely 1,2-ethylenediamine, piperazine and 4-aminopiperidine was synthesized and subsequently evaluated in vitro against HL60 and HCT116 cancer cell lines. All the EA analogs, excluding 6a and 6c, showed anti-proliferative activity with IC50s in the micromolar range (less than 4 uM). Three derivatives 6b, 7b and 7e were selected for their interesting dual activity on HL60 cell line in order to be further evaluated against a panel of cancer cell lines (HCT116, A549, MCF7, PC3, U87-MG and SKOV3) as well as on MRC5 as a normal cell line. These compounds displayed IC50 values in nanomolar range against A549, MCF7, PC3 and HCT116 cell lines, deducing the discovery that piperazine or 4-aminopiperidine is the linker's best choice to develop EA analogs with highly potent anti-proliferative activities own up to 24 nM. Besides, in terms of selectivity, those linkers are more suitable offering safety ratios of up to 63.8.

PYRAZOLE DERIVATIVES FOR THE INHIBITION OF CDK' S AND GSK' S

The invention provides compounds of the formula (I), or salts, tautomers, N-oxides or solvates thereof wherein: R1 is selected from: (a) 2,6-dichlorophenyl; (b) 2,6-difluorophenyl; (c) a 2,3,6-trisubstituted phenyl group wherein the substituents for the phenyl group are selected from fluorine, chlorine, methyl and methoxy; (d) a group R0; (e) a group R a; (f) a group Rlb; (g) a group Rlc; (h) a group Rld; and 0) 2,6-difluorophenylamino ; wherein R )0υ, r R> llaa, T Rj I1bD, T R) I1cC, r R> Iidα, r R?2zaa, r R>22bD and RJ are as defined in the claims. The compounds have activity as inhibitors of cdk kinase (such as cdkl or cdk2) and glycogen synthase kinase-3 activity.