65120-81-2Relevant academic research and scientific papers
New reactions of phosgene with tertiary amines
Itaya, Taisuke,Kanal, Tae
, p. 101 - 104 (2007/10/03)
1-Benzylwye (3) underwent substitution at the 7-position in the presence of COCl2 and pyridine in THF to afford various products depending upon the post-treatment through 1,4-dihydropyridine (7) and carboxylic acid derivative (8). When Et3N was used instead of pyridine, it reacted with COCl2 to provide two enamines (18 and 19), together with diethylcarbamyl chloride (20), after treatment of the reaction mixture with MeOH.
Studies towards the synthesis of the fluorescent bases of phenylalanine transfer ribonucleic acids: synthesis of 7-methylwye isolated from extremely thermophilic archaebacteria.
Itaya,Mizutani,Takeda,Shioyama
, p. 284 - 291 (2007/10/02)
Acid- or base-catalyzed acylation of 1-benzylwye (7) provided the 7-substituted derivatives 9, 10, and 11 in poor yields. Although the reactions of lithiated 7 with electrophiles gave the 2-substituted derivatives 14, 15, 17, 20, 21, and 22, lithiation of
