651323-32-9

Upstream product

• 651323-31-8 methyl 3α-acetoxy,7α-(3'-iodobenzoyl)oxy-5β-cholan-24-oate 
• 1711-10-0 3-iodobenzoyl chloride 
• 474-25-9 chenodeoxycholic acid 
• 19684-68-5 (4R)-methyl 4-((3R,5R,7R,10S,13R,17R)-3-acetoxy-7-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate 
• 618-51-9 3-Iodobenzoic acid 
• 3057-04-3 chenodeoxycholic acid methyl ester 

Downstream Products

• 1359697-41-8 3α,16α,24-trihydroxy-7α-(3'-iodobenozyl)oxy-5β-cholane 
• 1359697-45-2 methyl 7α-(3'-iodobenozyl)oxy-3,16-dihydroxy-5β-cholan-24-oate 
• 1359731-65-9 methyl 3α,16β-dihydroxy-7α-(3'-iodobenozyl)oxy-5β-cholan-24-oate 
• 651323-33-0 methyl Δ^-16-3α-acetoxy-7α-(3'-iodobenzoyl)oxy-5β-cholan-24-oate 

Relevant academic research and scientific papers

Facile Synthesis, Aggregation Behavior, and Cholesterol Solubilization Ability of Avicholic Acid

(Equation presented) Avicholic acid, a major constituent of the bile of several avian species, was synthesized in eight steps from readily available chenodeoxycholic acid in 9% overall yield using Breslow's remote functionalization strategy in a key step. Micelle formation and equilibrium cholesterol solubilization properties were studied for avicholate in aqueous solution.

Avicholic acid: A lead compound from birds on the route to potent TGR5 modulators

Grounding on our former 3D QSAR studies, a knowledge-based screen of natural bile acids from diverse animal species has led to the identification of avicholic acid as a selective but weak TGR5 agonist. Chemical modifications of this compound resulted in the disclosure of 6α-ethyl-16-epi-avicholic acid that shows enhanced potency at TGR5 and FXR receptors. The synthesis, biological appraisals, and structure-activity relationships of this series of compounds are herein described. Moreover, a thorough physicochemical characterization of 6α-ethyl-16-epi-avicholic acid as compared to naturally occurring bile acids is reported and discussed.