65133-68-8

Basic information

• Product Name: [11C]-m-hydroxyephedrine
• Synonyms: [11C]-m-hydroxyephedrine
• CAS NO: 65133-68-8
• Molecular Weight: 181.235
• Mol File: 65133-68-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [11C]-m-hydroxyephedrine(CAS DataBase Reference)
• NIST Chemistry Reference: [11C]-m-hydroxyephedrine(65133-68-8)
• EPA Substance Registry System: [11C]-m-hydroxyephedrine(65133-68-8)

Safety Data

• Hazardous Substances Data: 65133-68-8(Hazardous Substances Data)

Upstream product

• 78523-29-2 1-hydroxy-1-(3-hydroxyphenyl)propan-2-one 
• 74-89-5 methylamine 
• 593-51-1 methylamine hydrochloride 
• 100-83-4 meta-hydroxybenzaldehyde 
• 90887-42-6 3-hydroxy-3-(3-hydroxyphenyl)-1-propyne 
• 54-49-9 (1R,2S)-metaraminol 

Relevant articles and documents

Synthesis and carbon-11 labeling of the stereoisomers of meta-hydroxyephedrine (HED) and meta-hydroxypseudoephedrine (HPED)

The synthesis of the four stereoisomers of carbon-11 labeled meta-hydroxyephedrine (HED) and meta-hydroxypseudoephedrine (HPED) was undertaken for evaluation of their in vivo kinetic behavior. The stereoisomers of HED and HPED were synthesized by conversion of their respective enantiomerically-pure, normethyl precursors (meta-hydroxyphenylpropanolamine stereoisomers) to the carbamate derivatives and subsequent reduction with lithium aluminum hydride. Direct N- [11C]methylation of the appropriate nomethyl precursor with [11C]methyl triflate and HPLC purification provided the radiotracers in 26-42% (average = 36%; n = 12) decay-corrected radiochemical yields in a 40 min synthesis time from end-of-bombardment. The specific activity of the radiotracers was 1260-1625 Ci/mmol (average = 1368 Ci/mmol; n = 8) at end-of-synthesis and the radiochemical purity > 98%.