651335-50-1 Usage
Molecular Structure
The compound consists of an indole ring with a sulfonylphenyl group attached at the 3-position and a piperidinyl group attached at the 1-position.
Heterocyclic Indole Moiety
The presence of the indole ring, which is a heterocyclic aromatic ring system, is responsible for the compound's biological activity.
Sulfonyl Group
The presence of the sulfonyl group (-SO2-) attached to the phenyl ring can impart specific chemical reactivity to the compound.
Piperidinyl Group
The presence of the piperidinyl group (a five-membered nitrogen-containing ring) may confer desirable pharmacological properties, as piperidine derivatives are known to exhibit a wide range of biological activities.
Pharmaceutical and Research Applications
Due to its structural features, the compound has potential pharmaceutical and research applications.
Further Investigation
Exploration of 1H-Indole, 3-(phenylsulfonyl)-1-(4-piperidinyl)- could lead to the development of new drugs and therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 651335-50-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,5,1,3,3 and 5 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 651335-50:
(8*6)+(7*5)+(6*1)+(5*3)+(4*3)+(3*5)+(2*5)+(1*0)=141
141 % 10 = 1
So 651335-50-1 is a valid CAS Registry Number.
651335-50-1Relevant academic research and scientific papers
3-(Arylsulfonyl)-1-(azacyclyl)-1H-indoles are 5-HT6 receptor modulators
Bernotas, Ronald C.,Antane, Schuyler,Shenoy, Rajesh,Le, Van-Duc,Chen, Ping,Harrison, Boyd L.,Robichaud, Albert J.,Zhang, Guo Ming,Smith, Deborah,Schechter, Lee E.
scheme or table, p. 1657 - 1660 (2010/07/03)
Novel 3-(arylsulfonyl)-1-(azacyclyl)-1H-indoles 6 were synthesized as potential 5-HT6 receptor ligands, based on constraining a basic side chain as either a piperidine or a pyrrolidine. Many of these compounds had good 5-HT6 binding affinity with Ki values 50 = 60 nM, Emax = 70%) and antagonists (6y: IC50 = 17 nM, Imax = 86%) were identified in a 5-HT6 adenylyl cyclase assay.
