95539-67-6

Basic information

• Product Name: Benzenamine, 2-[(phenylsulfonyl)methyl]-
• Synonyms: 2-Benzolsulfonylmethyl-anilin;Benzenamine,2-[(phenylsulfonyl)methyl];2-[(benzenesulfonyl)methyl]aniline;2-phenylsulfonylmethylaniline;2-aminobenzyl phenyl sulfone;Phenyl-(2-amino-benzyl)-sulfon
• CAS NO: 95539-67-6
• Molecular Formula: C13H13NO2S
• Molecular Weight: 247.318
• Mol File: 95539-67-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 174 °C
• Boiling Point: 488.8±37.0 °C(Predicted)
• Density: 1.273±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzenamine, 2-[(phenylsulfonyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 2-[(phenylsulfonyl)methyl]-(95539-67-6)
• EPA Substance Registry System: Benzenamine, 2-[(phenylsulfonyl)methyl]-(95539-67-6)

Safety Data

• Hazardous Substances Data: 95539-67-6(Hazardous Substances Data)

Upstream product

• 873-55-2 sodium benzenesulfonate 
• 98-95-3 nitrobenzene 
• 612-23-7 2-nitrobenzyl chloride 
• 7205-98-3 chloromethyl phenyl sulfone 
• 69709-34-8 2-(phenylsulfonylmethyl)-1-nitrobenzene 

Downstream Products

• 108378-69-4 (2-Benzenesulfonylmethyl-phenyl)-[1-(4-bromo-phenyl)-meth-(E)-ylidene]-amine 
• 6127-49-7 2-(4-bromophenyl)indole 
• 651335-52-3 C₁₉H₂₀N₂O₂S 
• 651335-50-1 C₁₉H₂₀N₂O₂S 
• 651335-54-5 C₁₈H₁₈N₂O₂S 
• 154959-89-4 Toluolsulfonsaeure 1-(2-benzolsulfonylmethyl-phenyl)-4-oxoazetidin-2-ylmethylester 
• 154959-94-1 4-Benzolsulfonyl-3-ethoxy-3-trimethylsilyloxy-2,2a,3,4-tetrahydro-azeto<1,2-a>-chinolin-1-on 
• 154959-87-2 1-(2-Phenylsulfonylmethyl-phenyl)-4-styryl-2-azetidinon 
• 154959-86-1 1-(2-Phenylsulfonylmethyl-phenyl)-4-oxoazetidin-2-carbonsaeureethylester 
• 154959-88-3 1-(2-Benzolsulfonylmethyl-phenyl)-4-hydroxymethyl-2-azetidinon 
• 790657-30-6 N,N-dimethyl-N-{2-[3-(phenylsulfonyl)-1H-indol-1-yl]ethyl}amine 
• 107267-01-6 2-methyl-3-(phenylsulfonyl)-1H-indole 
• 133437-43-1 3-(phenylsulfonyl)-1H-indole 
• 60986-51-8 2-[2-phenylethenyl]-1H-indole 

Relevant articles and documents

3-(Arylsulfonyl)-1-(azacyclyl)-1H-indoles are 5-HT6 receptor modulators

Novel 3-(arylsulfonyl)-1-(azacyclyl)-1H-indoles 6 were synthesized as potential 5-HT6 receptor ligands, based on constraining a basic side chain as either a piperidine or a pyrrolidine. Many of these compounds had good 5-HT6 binding affinity with Ki values 50 = 60 nM, Emax = 70%) and antagonists (6y: IC50 = 17 nM, Imax = 86%) were identified in a 5-HT6 adenylyl cyclase assay.

1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-indoles as novel 5-HT6 receptor ligands

Novel 1-(2-aminoethyl)-3-(arylsulfonyl)-1H-indoles were prepared. Binding assays indicated they are 5-HT6 receptor ligands, among which N,N-dimethyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8t and N-methyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8u showed high affinity for 5-HT6 receptors with Ki = 3.7 and 5.7 nM, respectively. Novel 1-(2-aminoethyl)-3-(arylsulfonyl)-1H-indoles were prepared. Binding assays indicated they are 5-HT6 receptor ligands, among which N,N-dimethyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8t and N-methyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8u showed high affinity for 5-HT6 receptors with Ki = 3.7 and 5.7 nM, respectively.

A Facile Synthesis of 3-Sulfonyl-Substituted Indole Derivatives

A new method for the synthesis of 3-sulfonyl-substituted indole derivatives 5 was developed starting from the easily available products of the vicarious nucleophilic substitution of hydrogen in nitroarenes 1.