95539-67-6

Upstream product

• 69709-34-8 2-(phenylsulfonylmethyl)-1-nitrobenzene 
• 98-95-3 nitrobenzene 
• 873-55-2 sodium benzenesulfonate 
• 7205-98-3 chloromethyl phenyl sulfone 
• 612-23-7 2-nitrobenzyl chloride 

Downstream Products

• 948-65-2 2-phenyl-indole 
• 108378-68-3 2-benzylideneaminobenzyl phenyl sulfone 
• 108378-69-4 (2-Benzenesulfonylmethyl-phenyl)-[1-(4-bromo-phenyl)-meth-(E)-ylidene]-amine 
• 6127-49-7 2-(4-bromophenyl)indole 
• 869301-68-8 N-(2-benzenesulfonylmethyl-phenyl)-2,2,2-trifluoro-acetamide 
• 154959-88-3 1-(2-Benzolsulfonylmethyl-phenyl)-4-hydroxymethyl-2-azetidinon 
• 154959-86-1 1-(2-Phenylsulfonylmethyl-phenyl)-4-oxoazetidin-2-carbonsaeureethylester 
• 154959-87-2 1-(2-Phenylsulfonylmethyl-phenyl)-4-styryl-2-azetidinon 
• 154959-94-1 4-Benzolsulfonyl-3-ethoxy-3-trimethylsilyloxy-2,2a,3,4-tetrahydro-azeto<1,2-a>-chinolin-1-on 
• 154959-89-4 Toluolsulfonsaeure 1-(2-benzolsulfonylmethyl-phenyl)-4-oxoazetidin-2-ylmethylester 
• 651335-54-5 C₁₈H₁₈N₂O₂S 
• 651335-50-1 C₁₉H₂₀N₂O₂S 
• 651335-52-3 C₁₉H₂₀N₂O₂S 
• 790657-30-6 N,N-dimethyl-N-{2-[3-(phenylsulfonyl)-1H-indol-1-yl]ethyl}amine 

Relevant academic research and scientific papers

3-(Arylsulfonyl)-1-(azacyclyl)-1H-indoles are 5-HT6 receptor modulators

Novel 3-(arylsulfonyl)-1-(azacyclyl)-1H-indoles 6 were synthesized as potential 5-HT6 receptor ligands, based on constraining a basic side chain as either a piperidine or a pyrrolidine. Many of these compounds had good 5-HT6 binding affinity with Ki values 50 = 60 nM, Emax = 70%) and antagonists (6y: IC50 = 17 nM, Imax = 86%) were identified in a 5-HT6 adenylyl cyclase assay.

Novel synthesis of 2-aryl and 2,3-disubstituted indoles by modified double elimination protocol

(Chemical Equation Presented) Syntheses of 2-aryl and 2,3-substituted indoles were realized by modified double elimination protocol. Under basic conditions, vinyl sulfones derived from the reaction of 2-aminobenzyl sulfone with benzaldehydes underwent cyclization and alkylation followed by elimination of sulfinic acid to afford 2,3-substituted indoles.

1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-indoles as novel 5-HT6 receptor ligands

Novel 1-(2-aminoethyl)-3-(arylsulfonyl)-1H-indoles were prepared. Binding assays indicated they are 5-HT6 receptor ligands, among which N,N-dimethyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8t and N-methyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8u showed high affinity for 5-HT6 receptors with Ki = 3.7 and 5.7 nM, respectively. Novel 1-(2-aminoethyl)-3-(arylsulfonyl)-1H-indoles were prepared. Binding assays indicated they are 5-HT6 receptor ligands, among which N,N-dimethyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8t and N-methyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8u showed high affinity for 5-HT6 receptors with Ki = 3.7 and 5.7 nM, respectively.

1-Heterocyclylalkyl-3-sulfonyl-indole or -indazole derivatives as 5-hydroxytryptamine-6 ligands

The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.

A Facile Synthesis of 3-Sulfonyl-Substituted Indole Derivatives

A new method for the synthesis of 3-sulfonyl-substituted indole derivatives 5 was developed starting from the easily available products of the vicarious nucleophilic substitution of hydrogen in nitroarenes 1.