193344-39-7

Basic information

• Product Name: 2-broMo-6-(4-Methoxyphenyl)pyridine
• Synonyms: 2-broMo-6-(4-Methoxyphenyl)pyridine
• CAS NO: 193344-39-7
• Molecular Formula: C₁₂H₁₀BrNO
• Molecular Weight: 264.1179
• Mol File: 193344-39-7.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-broMo-6-(4-Methoxyphenyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-broMo-6-(4-Methoxyphenyl)pyridine(193344-39-7)
• EPA Substance Registry System: 2-broMo-6-(4-Methoxyphenyl)pyridine(193344-39-7)

Safety Data

• Hazardous Substances Data: 193344-39-7(Hazardous Substances Data)

Upstream product

• 626-05-1 2,6-Dibromopyridine 
• 5720-07-0 4-methoxyphenylboronic acid 
• 696-62-8 para-iodoanisole 
• 440680-34-2 (6-bromopyridin-2-yl)boronic acid 
• 651358-83-7 2-bromo-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 254454-47-2 4-methoxyphenylzinc iodide 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 234111-08-1 2-iodo-6-bromopyridine 

Downstream Products

• 21172-80-5 2,6-bis-(4'-methoxyphenyl)pyridine 
• 163851-08-9 5,5'-di(anisol-4-yl)-2,2'-bipyridine 
• 1583248-56-9 C₃₂H₃₄N₂O₂*C₃₃H₄₈N₄O 
• 1583248-47-8 6-(4-methoxyphenyl)-6'-(3-(4-methoxyphenyl)propyl)-2,2'-bipyridine 
• 1583248-48-9 4-(3-(6'-(4-hydroxyphenyl)-[2,2'-bipyridin]-6-yl)propyl)phenol 

Relevant articles and documents

Synthesis of polystyrene-supported Pd(II)-containing macrocyclic complex as a reusable catalyst for chemoselective Suzuki–Miyaura coupling reaction

A polystyrene-supported Pd complex bearing a cyclic pyridine-2,6-bisiamide ligand was synthesized and its catalytic activity in the Suzuki–Miyaura coupling reaction of 2,6-bromopyridine with 4-methoxyphenylboronic acid in aqueous media was investigated. The solid-supported catalyst exhibited catalytic activity and chemoselectivity that were comparable to those of homogeneous catalyst. The reusability of the solid-supported catalyst was also examined.

Design, synthesis, and biological evaluation of novel pyridine-bridged analogues of combretastatin-A4 as anticancer agents

A series of novel pyridine-bridged analogues of combretastatin-A4 (CA-4) were designed and synthesized. As expected, the 4-atom linker configuration retained little cytotoxicities in the compounds 2e, 3e, 3g, and 4i. Activities of the analogues with 3-atom linker varied widely depending on the phenyl ring substitutions, and the 3-atom linker containing nitrogen represents the more favorable linker structure. Among them, three analogues (4h, 4s, and 4t) potently inhibited cell survival and growth, arrested cell cycle, and blocked angiogenesis and vasculature formation in vivo in ways comparable to CA-4. The superposition of 4h and 4s in the colchicine-binding pocket of tubulin shows the binding posture of CA-4, 4h, and 4s are similar, as confirmed by the competitive binding assay where the ability of the ligands to replace tubulin-bound colchicine was measured. The binding data are consistent with the observed biological activities in antiproliferation and suppression of angiogenesis but are not predictive of their antitubulin polymerization activities.

A study on the selectivity of arylzinc reagents in cross-coupling reactions with chemically equivalent and pseudo-equivalent dibromopyridines

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