65148-10-9

Usage

Uses

Used in Pharmaceutical Research and Development:
6-Bromoquinoline-2-carboxylic acid is utilized as a key building block in the synthesis of pharmaceuticals, particularly for the development of antimalarial and antitumor drugs. Its unique structure allows for the creation of new drug candidates with potential therapeutic benefits in treating these diseases.
Used in Agrochemical Production:
In the agrochemical industry, 6-Bromoquinoline-2-carboxylic acid serves as a crucial intermediate in the synthesis of various agrochemicals, contributing to the development of effective pest control agents and other agricultural products.
Used in Organic Synthesis:
6-Bromoquinoline-2-carboxylic acid is employed as a precursor in organic synthesis, where it can be used to create a variety of organic compounds with diverse applications in different fields.
Used in the Production of Fluorescent Dyes:
6-Bromoquinoline-2-carboxylic acid is used as a starting material in the production of fluorescent dyes. These dyes have applications in various areas, including bioimaging, diagnostics, and as markers in research settings, due to their fluorescent properties.

InChI:InChI=1/C10H6BrNO2/c11-7-2-4-8-6(5-7)1-3-9(12-8)10(13)14/h1-5H,(H,13,14)

Upstream product

• 1020567-35-4 6-bromo-2-(tribromomethyl)quinoline 
• 877-42-9 6-Bromo-2-methyl-quinoline 
• 29124-57-0 2-amino-5-bromobenzaldehyde 
• 57-60-3 piruvate 
• 20357-20-4 5-bromo-2-nitrobenzaldehyde 
• 106-40-1 4-bromo-aniline 
• 65185-41-3 6-bromoquinoline-2-carbonitrile 
• 6563-11-7 6-bromoquinoline-N-oxide 
• 5332-25-2 6-bromoquinoline 
• 623583-88-0 methyl 6-bromo-2-quinolinecarboxylate 

Downstream Products

• 219959-35-0 N-tert.butyl-decahydro-2-[2-(R)-hydroxy-4-phenyl-3(S)-[{N-(2-[6-bromo]-quinolylcarbonyl)-L-asparaginyl}amino]butyl]-(4aS,8aS)-isoquinoline-3-carboxamide 
• 791626-58-9 2-amino-6-bromoquinoline 
• 1312609-38-3 C₃₉H₃₇N₇O₄ 
• 1312611-23-6 C₃₆H₃₉N₇O₆ 
• 1312611-83-8 C₃₁H₃₁N₇O₄ 
• 1312611-24-7 C₃₉H₃₇N₇O₅ 
• 1312611-25-8 C₃₁H₃₁N₇O₃ 
• 1312609-34-9 C₃₈H₄₂N₈O₆ 
• 1312611-26-9 C₃₈H₄₂N₈O₇ 
• 1312609-41-8 C₃₈H₄₂N₈O₆ 
• 1312609-37-2 C₄₀H₃₈N₆O₄ 
• 1312611-34-9 C₃₇H₄₀N₆O₆ 
• 1312611-36-1 C₃₇H₄₀N₆O₅ 
• 1312611-86-1 C₃₂H₃₂N₆O₃ 

Relevant academic research and scientific papers

Repurposing an Aldolase for the Chemoenzymatic Synthesis of Substituted Quinolines

Quinoline derivatives are important natural products and pharmaceuticals, but their synthesis can be challenging due to poor yields, harsh reaction conditions, and instability of starting materials. Here we report the chemoenzymatic synthesis of quinaldic acids under mild conditions using an aldolase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (NahE, or HBPA). A series of 2-aminobenzaldehydes derived from reduction of the corresponding nitro analogue were reacted with pyruvate in the presence of NahE to give substituted quinolines in up to 93% isolated yield. This reaction differs from the aldol condensation catalyzed by NahE in vivo, instead resembling the heterocycle formation catalyzed by its homologue, dihydrodipicolinate synthase.

COMPOUNDS FOR MODULATING FXR

Provided herein are compounds of Formula (I), a stereoisomer, enantiomer or a pharmaceutically acceptable salt thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesoid X receptors (FXR).

Discovery and efficient synthesis of a biologically active alkaloid inspired by thiostrepton biosynthesis

Thiostrepton, a natural peptide macrocycle, is of great interest due to its structural complexity and numerous biological activities, including anti-bacterial, anti-tumor, and anti-plasmodial activities. The quinaldic acid (QA) moiety-containing side ring (loop 2) was proven to play an important role in carrying out these functions. Previously, we proposed biosynthetic logic for thiostrepton loop 2 and demonstrated the formation mechanism of QA. Herein, we report the discovery and efficient synthesis of a biologically active alkaloid, that is, a key intermediate involved in the thiostrepton biosynthetic pathway. A chemo-enzymatic method was performed to synthesize the molecule, and a series of analogs were prepared for bioassays, which included the examination of anti-bacterial and anti-tumor activities.

GEMINALLY SUBSTITUTED CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

PYRIDONE DERIVATIVES

The present invention discloses phenylpyridone derivative compounds. The compounds act as a melanin concentrating hormone receptor antagonists, and can be used in preventing, treating or acting as a remedial agent for various circular system diseases, nervous system diseases, metabolic diseases, genital diseases, respiratory diseases and digestive diseases.

NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION

The embodiments provide compounds of the general Formulae I, II, III, IV, or V as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

Vanilloid receptor ligands and their use in treatments

Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

Bicyclo 4.4.0 antiviral derivatives

This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with amido piperazine derivatives. These compounds possess unique antiviral activity

The synthesis of labelled forms of saquinavir

The development of the HIV-protease inhibitor, saquinavir (Ro 31-8959), required a range of analytical methods for the measurement of the parent drug and drug-related material in biological fluids. This paper describes the synthesis of 14-carbon and tritium labelled compounds used for in vivo and in vitro investigations of the absorption and disposition of saquinavir in animals and man. It also discusses the preparation of saquinavir labelled with deuterium and stable isotopes of carbon and nitrogen. These forms of the drug were needed for bioequivalence studies in which HPLC/MS/MS was employed for the measurement of plasma concentrations. Finally, the synthesis of a 125-iodine labelled tracer used in a radioimmunoassay for saquinavir is described.