197151-80-7

Upstream product

• 223378-68-5 N¹⁰-(trifluoroacetyl)pyrofolic acid 
• 223378-69-6 pyrofolic acid 
• 197151-79-4 pteroyl azide 
• 59-30-3 folic acid 
• 197151-68-1 pteroyl hydrazide 

Downstream Products

• 197151-79-4 pteroyl azide 
• 197151-85-2 N²-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzoyl)-N⁵-(2-aminoethyl)-L-glutamine 
• 53464-60-1 L-methyl folate (γ) 
• 65165-92-6 folate 
• 65165-91-5 D-folic acid 

Relevant academic research and scientific papers

Efficient syntheses of pyrofolic acid and pteroyl azide, reagents for the production of carboxyl-differentiated derivatives of folic acid

Reaction of folic acid (1) with excess trifluoroacetic anhydride provides access to both the previously unknown N10-(trifluoroacetyl)pyrrofolic acid (8) and pyrofolic acid (9). Reaction of either of these materials with hydrazine selectively affords pteroyl hydrazide (13), which may be oxidized to pteroyl azide (27) on a large scale (62% overall from I without the need for chromatography). Treatment of 27 with differentially protected glutamates provides a convenient and high-yielding synthesis of differentially protected, optically pure folates.

Folate-modified cholesterol-bearing pullulan as a drug carrier

Folate modified cholesterol-bearing pullulan (FA-CHP) was synthesized by the reaction of folic acid γ-2-aminoethylamide and 4-nitorophenyl chloroformate-activated cholesterol-bearing pullulan, wherein folate and pullulan are connected through a NH—CH