65178-24-7Relevant academic research and scientific papers
A modern approach to the synthesis of 2-(4-chlorophenyl)[2- 14C]thiazol-4-ylacetic acid ([14C] fenclozic acid) and its acyl glucuronide metabolite
Killick, David A.,Bushby, Nick
, p. 17 - 21 (2013)
An updated approach to the 1960s synthesis of [14C] fenclozic acid from labelled potassium cyanide is presented. By employing modern synthetic methodology and purification techniques, many of the inherent hazards in the original synthesis are avoided or significantly reduced. The concomitant labelled stereoselective synthesis of the key acyl glucuronide metabolite (the 1-β-O-acyl glucuronide) is also described. [14C]Fenclozic acid and its key acyl glucuronide metabolite, the 1-β-O-acyl glucuronide were prepared from labelled potassium cyanide. [14C]Fenclozic acid had previously been prepared in the 1960s, however in this paper we describe a shorter synthesis that avoids or reduces some of the inherent hazards present in the original synthesis. Copyright
