65205-55-2

Upstream product

• 201230-82-2 carbon monoxide 
• 5373-87-5 (Z)-N'-hydroxy-4-methoxybenzenecarboximidamide 
• 14271-73-9 4-methylbenzoyl cyanide 
• 5373-87-5 4-methoxybenzamidoxime 
• 874-90-8 4-methoxybenzonitrile 
• 16013-13-1 3-(4-methoxyphenyl)-1,2,4-oxadiazole 
• 624-31-7 4-tolyl iodide 

Downstream Products

• 72093-98-2 3'-(4-methoxy-phenyl)-5-phenyl-3,5'-(4,4'-trans-ethene-1,2-diyl-diphenyl)-bis-[1,2,4]oxadiazole 
• 65204-84-4 5-{4-[4-(2,5-diphenyl-2H-[1,2,3]triazol-4-yl)-styryl]-phenyl}-3-(4-methoxy-phenyl)-[1,2,4]oxadiazole 
• 65204-97-9 5-{4-[4-(4,5-diphenyl-[1,2,3]triazol-2-yl)-styryl]-phenyl}-3-(4-methoxy-phenyl)-[1,2,4]oxadiazole 
• 65965-69-7 2-(4-{4-[3-(4-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-styryl}-phenyl)-[1,2,4]triazolo[1,5-a]pyridine 
• 71944-56-4 3-(4-methoxy-phenyl)-5-{4-[4-(1-phenyl-1H-pyrazol-3-yl)-styryl]-phenyl}-[1,2,4]oxadiazole 
• 72093-88-0 2-(3-chloro-4-{4-[3-(4-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-trans-styryl}-phenyl)-benzooxazole 
• 72093-87-9 2-(4-{4-[3-(4-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-trans-styryl}-phenyl)-5-methyl-benzooxazole 
• 64893-30-7 2-(4-{4-[3-(4-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-trans-styryl}-phenyl)-benzooxazole 
• 72094-17-8 5-(4-{2-chloro-4-[5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-trans-styryl}-phenyl)-3-(4-methoxy-phenyl)-[1,2,4]oxadiazole 
• 72094-27-0 2-(3-chloro-4-{4-[3-(4-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-trans-styryl}-phenyl)-2H-naphtho[1,2-d][1,2,3]triazole 
• 72094-42-9 4-chloro-N-{4-[3-(4-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-benzylidene}-aniline 
• 72094-41-8 4-(3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl)benzaldehyde 
• 65204-72-0 3-(4-methoxy-phenyl)-5-{4-[4-(2-phenyl-2H-[1,2,3]triazol-4-yl)-styryl]-phenyl}-[1,2,4]oxadiazole 
• 65204-87-7 3-(4-methoxy-phenyl)-5-{4-[4-(4-phenyl-[1,2,3]triazol-2-yl)-styryl]-phenyl}-[1,2,4]oxadiazole 

Relevant academic research and scientific papers

Imidazole hydrochloride promoted synthesis of 3,5-disubstituted-1,2,4-oxadiazoles

Imidazole hydrochloride as an additive promotes the reaction of amidoximes and DMA derivatives to generated 3,5-disubstituted-1,2,4-oxadiazoles in low to excellent yields without the use of coupling reagents, oxidants, strong acids or bases and other additives.

Palladium-Catalyzed, Silver-Assisted Direct C-5–H Arylation of 3-Substituted 1,2,4-Oxadiazoles under Microwave Irradiation

A direct C-5–H arylation of 3-substituted 1,2,4-oxadiazoles with aryl iodides in the presence of a palladium catalyst and silver acetate is reported. This method provides a rapid, reliable way to obtain versatile 3,5-diaryl-1,2,4-oxadiazole derivatives, which are common moieties of many biologically active molecules. The synthetic applications of this novel method have been demonstrated in the concise syntheses of Ataluren and a potent RET inhibitor Yhhu251. (Figure presented.).

Microwave assisted synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from substituted amidoximes and benzoyl cyanides

We report herein the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from amidoximes and substituted or unsubstituted benzoyl cyanides under microwave irradiation. Substituted or unsubstituted O-carboxyphenyl amidoxime is a key intermediate of this alternative method developed for the synthesis of these heterocycles. These reactions employ simple synthetic protocols devoid of lengthy purification procedures and proceed with good yield.

Hypervalent iodine in synthesis. 75. A convenient synthesis of oxadiazoles by palladium-catalyzed carbonylation and cyclization of diaryliodonium salts and amidoximes

3,5-Disubstituted-1,2,4-oxadiazoles were prepared in one-pot procedure in moderate yields via the palladium-catalyzed carbonylation of diaryliodonium salts with amidoximes under one atmosphere of carbon monoxide followed by intramolecular dehydrative cycl