72094-41-8

Upstream product

• 72094-40-7 5-(4-bromomethyl-phenyl)-3-(4-methoxy-phenyl)-[1,2,4]oxadiazole 
• 16013-13-1 3-(4-methoxyphenyl)-1,2,4-oxadiazole 
• 15164-44-0 p-(iodophenyl)carboxaldehyde 
• 5373-87-5 N-hydroxy-4-methoxybenzene-1-carboximidamide 
• 874-90-8 4-methoxybenzonitrile 
• 65205-55-2 3-(4-methoxyphenyl)-5-(4-methylphenyl)-1,2,4-oxadiazole 

Downstream Products

• 72094-42-9 4-chloro-N-{4-[3-(4-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-benzylidene}-aniline 
• 72093-88-0 2-(3-chloro-4-{4-[3-(4-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-trans-styryl}-phenyl)-benzooxazole 
• 72093-87-9 2-(4-{4-[3-(4-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-trans-styryl}-phenyl)-5-methyl-benzooxazole 
• 64893-30-7 2-(4-{4-[3-(4-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-trans-styryl}-phenyl)-benzooxazole 
• 72094-17-8 5-(4-{2-chloro-4-[5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-trans-styryl}-phenyl)-3-(4-methoxy-phenyl)-[1,2,4]oxadiazole 
• 72094-27-0 2-(3-chloro-4-{4-[3-(4-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-trans-styryl}-phenyl)-2H-naphtho[1,2-d][1,2,3]triazole 
• 72094-16-7 5-{4-[2-chloro-4-(5-phenyl-[1,3,4]oxadiazol-2-yl)-trans-styryl]-phenyl}-3-(4-methoxy-phenyl)-[1,2,4]oxadiazole 
• 72094-23-6 2-(3-chloro-4-{4-[3-(4-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-trans-styryl}-phenyl)-2H-benzo[1,2,3]triazole 

Relevant academic research and scientific papers

Palladium-Catalyzed, Silver-Assisted Direct C-5–H Arylation of 3-Substituted 1,2,4-Oxadiazoles under Microwave Irradiation

A direct C-5–H arylation of 3-substituted 1,2,4-oxadiazoles with aryl iodides in the presence of a palladium catalyst and silver acetate is reported. This method provides a rapid, reliable way to obtain versatile 3,5-diaryl-1,2,4-oxadiazole derivatives, which are common moieties of many biologically active molecules. The synthetic applications of this novel method have been demonstrated in the concise syntheses of Ataluren and a potent RET inhibitor Yhhu251. (Figure presented.).