652131-05-0Relevant academic research and scientific papers
Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors
Angibaud, Patrick,Bourdrez, Xavier,End, David W.,Freyne, Eddy,Janicot, Michel,Lezouret, Patricia,Ligny, Yannick,Mannens, Geert,Damsch, Siegrid,Mevellec, Laurence,Meyer, Christophe,Muller, Philippe,Pilatte, Isabelle,Poncelet, Virginie,Roux, Bruno,Smets, Gerda,Van Dun, Jacky,Van Remoortere, Pieter,Venet, Marc,Wouters, Walter
, p. 4365 - 4369 (2007/10/03)
A series of (4-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl) azoloquinolines and -quinazolines was prepared. These compounds displayed potent Farnesyl Protein Transferase inhibitory activity and tetrazolo[1,5-a] quinazolines are promising agents for oral in vivo inhibition.
