192187-32-9

Basic information

• Product Name: 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)quinolin-2(1H)-one
• Synonyms: 2(1H)-quinolinone, 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-; 6-(4-Chlorobenzoyl)-4-(3-chlorophenyl)quinolin-2(1H)-one
• CAS NO: 192187-32-9
• Molecular Formula: C₂₂H₁₃Cl₂NO₂
• Molecular Weight: 394.2501
• Mol File: 192187-32-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 624.694°C at 760 mmHg
• Flash Point: 331.603°C
• Density: 1.377g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.659
• CAS DataBase Reference: 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)quinolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)quinolin-2(1H)-one(192187-32-9)
• EPA Substance Registry System: 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)quinolin-2(1H)-one(192187-32-9)

Safety Data

• Hazardous Substances Data: 192187-32-9(Hazardous Substances Data)

Upstream product

• 406161-72-6 N-[4-bromo-2-(3-chlorobenzoyl)phenyl]acetamide 
• 280143-23-9 6-bromo-2-chloro-4-(3-chlorophenyl)quinoline 
• 190898-86-3 6-bromo-4-(3-chloro-phenyl)-2-methoxy-quinoline 
• 192187-30-7 4-(3-chlorophenyl)-3,4-dihydro-2(1H)-quinolinone 
• 288391-73-1 5-Bromo-3-(3-chloro-phenyl)-benzo[c]isoxazole 
• 190898-77-2 3-(3-chlorophenyl)-5-[2-(4-chlorophenyl)-1,3-dioxolan-2-yl]-2,1-benzisoxazole 
• 190898-78-3 [2-amino-5-(4-chlorobenzoyl)phenyl](3-chlorophenyl)-methanone 
• 190898-64-7 2-(4-Chlorophenyl)-2-(4-nitrophenyl)-1,3-dioxolane 
• 74-11-3 para-chlorobenzoic acid 
• 65247-25-8 (2-amino-5-bromo-phenyl)-(3-chloro-phenyl)-methanone 
• 7497-60-1 (4-Chlorophenyl)(4-nitrophenyl)methanone 
• 192187-31-8 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-3,4-dihydro-2(1H)-quinolinone 
• 406162-21-8 (4-chlorophenyl)-[4-(3-chlorophenyl)-2-methoxyquinolin-6-yl]methanone 
• 405548-67-6 N-[2-(3-chlorobenzoyl)-4-(4-chlorobenzoyl)phenyl]acetamide 

Downstream Products

• 280144-86-7 [2-chloro-4(3-chlorophenyl)-6-quinolinyl](4-chlorophenyl)-methanone hydrochloride 
• 260052-50-4 6-(4-Chloro-benzoyl)-4-(3-chloro-phenyl)-1-cyclopropylmethyl-1H-quinolin-2-one 
• 280144-89-0 5-(3-chlorophenyl)-α-(4-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl)-imidazol[1,2-a]quinoline-7-methanol 
• 652131-05-0 (4-chloro-phenyl)-[5-(3-chloro-phenyl)-[1,2,4]triazolo[4,3-a]quinolin-7-yl]-(3-methyl-3H-imidazol-4-yl)-methanol 
• 280143-37-5 (4-chloro-phenyl)-[4-(3-chloro-phenyl)-2-(2,2-dimethoxy-ethylamino)-quinolin-6-yl]-methanone 
• 280143-17-1 (+/-)-2-chloro-4-(3-chlorophenyl)-α-(4-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl)-6-quinolinemethanol 
• 280143-27-3 (4-chloro-phenyl)-[5-(3-chloro-phenyl)-[1,2,4]triazolo[4,3-a]quinolin-7-yl]-methanone 
• 280143-38-6 (4-chloro-phenyl)-[5-(3-chloro-phenyl)-imidazo[1,2-a]quinolin-7-yl]-methanone 
• 192185-72-1 tipifarnib 
• 192185-68-5 6-[amino(4-chlorophenyl)-1-methyl-1H-imidazol-5-ylmethyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone 
• 192185-51-6 4-(3-chlorophenyl)-6-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-1-methyl-2(1H)-quinolinone 
• 192187-33-0 R₁₀₄₂₀₉ 
• 280144-85-6 [2-chloro-4-(3-chloro-phenyl)-quinolin-6-yl]-(4-chloro-phenyl)-methanone 

Relevant articles and documents

Practical route to 2-quinolinones via a Pd-catalyzed C-H bond activation/C-C bond formation/cyclization cascade reaction

Quinolinone derivatives were constructed via a Pd-catalyzed C-H bond activation/C-C bond formation/cyclization cascade process with simple anilines as the substrates. This finding provides a practical procedure for the synthesis of quinolinone-containing alkaloids and drug molecules. The utility of this method was demonstrated by a formal synthesis of Tipifarnib.

Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors

A series of (4-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl) azoloquinolines and -quinazolines was prepared. These compounds displayed potent Farnesyl Protein Transferase inhibitory activity and tetrazolo[1,5-a] quinazolines are promising agents for oral in vivo inhibition.

Farnesyl protein transferase inhibiting (imidazol-5-yl)methyl-2-quionlinone derivatives

PCT No. PCT/EP96/04515 Sec. 371 Date May 26, 1998 Sec. 102(e) Date May 26, 1998 PCT Filed Oct. 16, 1996 PCT Pub. No. WO97/21701 PCT Pub. Date Jun. 19, 1997This invention comprises the novel compounds of formula (I) wherein the dotted line represents an op