652156-53-1

Usage

Purpose

Anti-obesity drug

Mechanism

Activates serotonin receptors in the brain to promote a feeling of fullness and reduce food intake

Target users

Adults with a BMI of 30 or greater, or adults with a BMI of 27 or greater who have at least one weight-related condition (e.g. high blood pressure, type 2 diabetes, or high cholesterol)

Potential risks

Increased risk of certain cancers

Market status

Withdrawn from the market in some countries

Upstream product

• 2759-28-6 1-phenylmethylpiperazine 
• 1943-79-9 N-Methyl-O-phenylcarbamat 
• 624-83-9 methyl isocyanate 
• 1885-14-9 phenyl chloroformate 
• 74-89-5 methylamine 

Downstream Products

• 163361-25-9 N-methyl-1-piperazinecarboxamide 

Relevant academic research and scientific papers

A very concise synthesis of a potent N-(1,3-thiazol-2-yl)pyridin-2-amine KDR kinase inhibitor

A very concise synthesis of a potent KDR kinase inhibitor 1 is described. The synthesis features an exceedingly efficient one-pot preparation of the aminothiazole 6 followed by Pd-Xantphos catalyzed cross-coupling with chloropyridine aldehyde 11. Reductiv

Active salt forms with tyrosine kinase activity

The present invention relates to orally active salt forms of the mesylate salt of 4-[2-(5-cyano-thiazol-2-ylamino)-pyridin-4-ylmethyl]-piperazine-1-carboxylic acid methylamide which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, retinal ischemia, macular edema, inflammatory diseases, and the like in mammals.

Polymorphs with tyrosine kinase activity

The present invention relates to active polymorphs of 4-[2-(5-cyano-thiazol-2-ylamino)-pyridin-4-ylmethyl]-piperazine-1-carboxylic acid methylamide which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angio-genesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, retinal ischemia, macular edema, inflammatory diseases, and the like in mammals.

Salt forms with tyrosine kinase activity

The present invention relates to salt forms of 4-[2-(5-cyano-thiazol-2-ylamino)-pyridin-4-ylmethyl]-piperazine-1-carboxylic acid methylamide which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angio-genesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, retinal ischemia, macular edema, inflammatory diseases, and the like in mammals.

PROCESS FOR MAKING SUBSTITUTED THIAZOLYL-AMINO PYRIDINES

The present invention relates to a process for preparing substituted thiazolyl-amino pyridines, which are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases