65267-38-1

Usage

Heterocyclic compound

A compound that contains a ring of atoms with at least one heteroatom (an atom other than carbon) In this case, the compound contains both a triazole and a pyrimidine ring.

Biological activities

The potential for the compound to have an effect on biological systems 2-(4-chlorophenyl)[1,2,4]triazolo[1,5-a]pyrimidine has potential as an antimicrobial and antifungal agent.

Therapeutic applications

The potential for the compound to be used in the treatment of diseases The compound is being studied for its potential use in the treatment of various diseases, including cancer and neurological disorders.

Unique structure

The compound has a distinctive structure that sets it apart from other compounds The presence of both a triazole and a pyrimidine ring makes the compound unique.

Potential for further study and development

The compound is of interest for further research due to its structure and potential therapeutic applications.

Upstream product

• 65267-37-0 3-(4-chlorophenyl)-1,2,4-triazolo[4,3-a]pyrimidine 
• 274-98-6 [1,2,4]triazolo[4,3-a]pyrimidine 
• 637-87-6 1-Chloro-4-iodobenzene 
• 623-03-0 4-Cyanochlorobenzene 
• 132635-69-9 4-Chloro-N-pyrimidin-2-yl-benzamidine 

Relevant academic research and scientific papers

Molecular Engineering of Mechanochromic Materials by Programmed C-H Arylation: Making a Counterpoint in the Chromism Trend

The development of facile methods for screening organic functional molecules through C-H bond activation is a revolutionary trend in materials research. The prediction of mechanochromism as well as mechanochromic trends of luminogens is an appealing yet challenging puzzle. Here, we present a strategy for the design of mechanochromic luminogens based on the dipole moment of donor-acceptor molecules. For this purpose, a highly efficient route to 2,7-diaryl-[1,2,4]triazolo[1,5-a]pyrimidines (2,7-diaryl-TAPs) has been established through programmed C-H arylation, which unlocks a great opportunity to rapidly assemble a library of fluorophores for the discovery of mechanochromic regularity. Molecular dipole moment can be employed to explain and further predict the mechanochromic trends. The 2,7-diaryl-TAPs with electron-donating groups on the 2-aryl and electron-withdrawing groups on the 7-aryl possess a relatively small dipole moment and exhibit a red-shifted mechanochromism. When the two aryls are interchanged, the resulting luminogens have a relatively large dipole moment and display a blue-shifted mechanochromism. Seven pairs of isomers with opposite mechanochromic trends are presented as illustrative examples. The aryl-interchanged congeners with a bidirectional emission shift are structurally similar, which provides an avenue for understanding in-depth the mechanochromic mechanism.

Product and Mechanism of Gas-phase Pyrolysis of 2-arylidinehydrazinopyrimidines: Interesting Route to Condensed Heterocycles [1]

Gas-phase pyrolysis of N-arylidine-N′-pyrimidin-2-yl-hydrazine derivatives 1a, 1b, 1c, 1d, 1e gave the corresponding arylnitriles 2a, 2b, 2c, 2d, 2e, 2-aminopyrimidine 3, 3-phenyl-1,2,4-triazolo[4,3-a]pyrimidines 4, 2-phenyl-1,2,4-triazolo[1,5-a]pyrimidines 5, 2,4,5-triphenyl-1H-imidazole 6, and 2,3-diphenylquinoline 7. The analyses of the reaction products are reported and used to elucidate the mechanism of the pyrolytic process.

Synthesis of 2-Aryl-1,2,4-triazolopyrimidines

N-2-Pyrimidylarylamidines (2) obtained by the reaction of 2-aminopyrimidines (1) with aryl cyanides in the presence of anhydrous aluminium chloride have been converted into 2-aryl-1,2,4-triazolopyrimidines (4) by oxidative cyclisation in the presence of lead tetraacetate.

Synthesis of 2-Aryltriazolopyrimidines

2-Aroylamino)pyrimidines (4) have been converted into 1-(2-pyrimidyl)-5-aryl-1H-tetrazoles (6) by treatment with PCl5 followed by azidolysis in aqueous acetone solution.Pyrolysis of 6 in decalin gave 2-aryltriazolopyrimidines (8).A reasonable pathway for the formation of 8 from 6 is suggested.Structures of all the compounds have been established by elemental analysis and spectral data.