65269-96-7Relevant academic research and scientific papers
An Easy, General and Practical Method for the Construction of Alkyl Sulfonyl Fluorides
Zhang, Xu,Fang, Wan-Yin,Lekkala, Ravindar,Tang, Wenjian,Qin, Hua-Li
supporting information, p. 3358 - 3363 (2020/07/13)
A visible light-induced reductive addition of 1°, 2° and 3° alkyl iodides to ethenesulfonyl fluoride, employing Hantzsch ester as a hydrogen source at room temperature was developed. This method featured a wide substrate scope and great functional group compatibility, providing facile and robust process to alkyl sulfonyl fluorides including enzyme inhibitors, natural products and drugs derivatives in up to 99percent yield. Further derivatization of resultant aliphatic sulfonyl fluorides was also achieved through sulfur fluoride exchange (SuFEx) reactions to deliver sulfonates and sulfonamides as privileged motifs for medicinal chemistry. (Figure presented.).
Inhibition of lipoprotein lipase by alkanesulfonyl fluorides
Kokotos, George,Kotsovolou, Stavroula,Constantinou-Kokotou, Violetta,Wu, Gengshu,Olivecrona, Gunilla
, p. 2803 - 2806 (2007/10/03)
A number of alkanesulfonyl halides (chlorides and fluorides) and esters were synthesized and their effect on the activity of lipoprotein lipase (LPL) was studied. Sulfonyl fluorides proved to be efficient inhibitors of LPL when the enzyme was incubated with a 10-fold molar excess of the inhibitors in a buffer containing bile salts (deoxycholate). Hexadecane- and dodecanesulfonyl fluorides caused 50% inhibition of LPL activity at concentrations of 10 to 20 μM. (C) 2000 Elsevier Science Ltd.
