65273-28-1

Basic information

• Product Name: o-allylphenylmagnesium bromide
• Synonyms: o-allylphenylmagnesium bromide
• CAS NO: 65273-28-1
• Molecular Weight: 221.379
• Mol File: 65273-28-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: o-allylphenylmagnesium bromide(CAS DataBase Reference)
• NIST Chemistry Reference: o-allylphenylmagnesium bromide(65273-28-1)
• EPA Substance Registry System: o-allylphenylmagnesium bromide(65273-28-1)

Safety Data

• Hazardous Substances Data: 65273-28-1(Hazardous Substances Data)

Upstream product

• 42918-20-7 1-allyl-2-bromobenzene 

Downstream Products

• 78602-32-1 o-prop-1-enylbenzophenone 
• 78602-30-9 o-prop-1-enylbenzophenone imine hydrochloride 
• 90930-93-1 N,N-Dimethyl-2-{1-[2-(2-oxo-ethyl)-phenyl]-cyclohex-2-enyl}-acetamide 
• 90930-92-0 2-[1-(2-Allyl-phenyl)-cyclohex-2-enyl]-N,N-dimethyl-acetamide 
• 90930-91-9 3-(2-Allyl-phenyl)-cyclohex-2-enol 
• 191546-87-9 3-(2-Allyl-phenyl)-5-methyl-cyclohex-2-enone 
• 90930-90-8 2’-allyl-5,6-dihydro-[1,1‘-biphenyl]-3(4H)-one 

Relevant articles and documents

Structural Studies on 4,5-Disubstituted 2-Aminoimidazole-Based Biofilm Modulators that Suppress Bacterial Resistance to β-Lactams

A library of 4,5-disubstituted 2-aminoimidazole triazole amide (2-AITA) conjugates has been successfully assembled. Upon biological screening, this class of small molecules was discovered as enhanced biofilm regulators through non-microbicidal mechanisms against methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Acinetobacter baumannii (MDRAB), with active concentrations in the low micromolar range. The library was also subjected to synergism and resensitization studies with β-lactam antibiotics against MRSA. Lead compounds were identified that suppress the antibiotic resistance of MRSA by working synergistically with oxacillin, a β-lactam antibiotic resistant to penicillinase. A further structure-activity relationship (SAR) study on the parent 2-AITA compound delivered a 2-aminoimidazole diamide (2-AIDA) conjugate with significantly increased synergistic activity with oxacillin against MRSA, decreasing the MIC value of the β-lactam antibiotic by 64-fold. Increased anti-biofilm activity did not necessarily lead to increased suppression of antibiotic resistance, which indicates that biofilm inhibition and resensitization are most likely occurring via distinct mechanisms.