65288-05-3

Upstream product

• 108-98-5 thiophenol 
• 104-55-2 3-phenyl-propenal 
• 22956-19-0 3-(phenylthio)hydrocinnamaldehyde 
• 100-42-5 styrene 
• 5425-50-3 3-phenyl-3-(phenylmercapto)propanoic acid 
• 103-36-6 ethyl 3-phenyl-2-propenoate 
• 59106-44-4 ethyl-3-phenyl-3-(phenylthio)propanoate 
• 14371-10-9 (E)-3-phenylpropenal 
• 75-21-8 oxirane 
• 831-91-4 Benzyl phenyl sulfide 

Downstream Products

• 65288-14-4 3-Phenylpropyloxymesyl-3-phenylsulfon 
• 65288-10-0 3-Phenyl-3-phenylsulfonyl-1-propanol 

Relevant academic research and scientific papers

Visible-Light-Driven Iron-Promoted Thiocarboxylation of Styrenes and Acrylates with CO2

The first thiocarboxylation of styrenes and acrylates with CO2 was realized by using visible light as a driving force and catalytic iron salts as promoters. A variety of important β-thioacids were obtained in high yields. This multicomponent reaction proceeds in an atom- and redox-economical manner with broad substrate scope under mild reaction conditions. Notably, high regio-, chemo-, and diasteroselectivity are observed. Mechanistic studies indicate that a radical pathway can account for the unusual regioselectivity.

Desulfurative Chlorination of Alkyl Phenyl Sulfides

The chlorination of readily available secondary and tertiary alkyl phenyl sulfides using (dichloroiodo)benzene (PhICl2) is reported. This mild and rapid nucleophilic chlorination is extended to sulfa-Michael derived sulfides, affording elimination-sensitive β-chloro carbonyl and nitro compounds in good yields. The chlorination of enantioenriched benzylic sulfides to the corresponding inverted chlorides proceeds with high stereospecificity, thus providing a formal entry into enantioenriched chloro-Michael adducts. A mechanism implying the formation of a dichloro-λ4-sulfurane intermediate is proposed.

TMAF-catalyzed conjugate addition of oxazolidinone and thiols

TMAF (Me4NF) is a useful catalyst for the conjugate addition of oxazolidinone and thiols to a range of Michael acceptors including esters, ketones, nitroolefins and cinnamaldehyde.

Preparation of thiochromans via thermal cyclization

Formation of the thiochroman ring system is achieved by a two step synthesis that involves heating 3-thiophenyl-1-propanols or 4-thiophenyl-2-butanols in toluene with catalytic amounts of p-toluenesulfonic acid. The propanols are made by the addition of s