65295-68-3

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-aminoethyl)-3-(2,6-dichlorophenyl)thiourea is used as a potential therapeutic agent for the treatment of certain medical conditions. Its specific application reason is not provided in the materials, but its potential use in medicine warrants further research and investigation into its properties and potential uses.
Used in Agricultural Industry:
1-(2-aminoethyl)-3-(2,6-dichlorophenyl)thiourea is used as a pesticide in the agricultural industry. The application reason is not explicitly stated in the materials, but its potential use as a pesticide suggests that it may have properties that are effective in controlling pests or protecting crops. Further research and investigation are needed to understand its full potential and safety in this application.

Upstream product

• 107-15-3 ethylenediamine 
• 6590-95-0 2,6-dichlorophenylisothiocyanate 

Downstream Products

• 65295-70-7 1-(2-aminoethyl)-3-(2,6-dichlorophenyl)-2-(metylthio)pseudourea 
• 4205-90-7 Clonidin 
• 65295-70-7 1-(2-aminoethyl)-3-(2,6-dichlorophenyl)-2-methylthiopseudourea 

Relevant academic research and scientific papers

A convenient method for the synthesis of 2-amino substituted aza-heterocycles from N,N′-disubstituted thioureas using TsCl/NaOH

p-Toluenesulfonyl chloride (TsCl)/NaOH has been introduced as reagent combination for the synthesis of 2-amino-oxa- or 2-amino-thiazolidines from N-(2-hydroxyethyl)-thioureas, but its general application in heterocycle synthesis has not been investigated. In this paper the convenient and efficient synthesis of a variety of 2-amino-substituted 1-aza 3-(aza, oxo or thio) heterocycles of different substitution and ring sizes is described. The application of polymer-supported TsCl facilitates work-up and renders the reaction conditions very suitable for parallel or robot synthesis. Graphical Abstract

Process for synthesizing heterocyclic compounds

The invention provides the process illustrated in scheme 1 for synthesizing heterocyclic compounds of formula I. In the process, an isothiocyanate of formula II is initially reacted with a primary amine of formula III to give a thiourea of formula IV. Subsequently, the thiourea of formula IV is converted to the corresponding heterocycle of formula I using a base and a sulfonyl chloride.

Antihypertensive (2-Aminoethyl)thiourea Derivatives. 1

Structure-activity studies were carried out on a series of antihypertensive 1-(2-aminoethyl)-3-(substituted phenyl)thioureas.From this class of compounds, the 2,6-dichlorophenyl analogue 2 was found to have potent oral antihypertensive activity in two hypertensive rat models and the renal hypertensive dog.In addition to its effect on blood pressure, 2 displayed sedative effects which had a marked species specificity.

Thiourea derivatives

Antihypertensively active thiourea derivatives of the formulas STR1 wherein R, R1, R2, R3 and X are as hereinafter described, as well as a method of using a compound of the formula STR2 wherein R1 ', R2 ', R3 and X are as previously described, or a compound of formula II as an anti-hypertensive agent, is described.