654-53-5

Usage

Chemical Properties

clear colorless liquid

InChI:InChI=1/C7HF7/c8-3-1-2(7(12,13)14)4(9)6(11)5(3)10/h1H

Upstream product

• 715-30-0 1-chloro-2,3,4,5-tetrafluoro-6-trifluoromethyl-benzene 
• 21724-11-8 2-Trifluormethyl-1,4,5,6,7,7,8,8-octafluor-bicyclo<2.2.2>octadien-(2,5) 
• 97985-54-1 2,3,4,5-tetrachloro-1-(trifluoromethyl)benzene 
• 2751-90-8 tetraphenylphosphonium bromide 
• 115812-33-4 2,3,4-trifluoro-5-chloro-trifluoromethylbenzene 
• 434-64-0 perfluorotoluene 

Downstream Products

• 66820-64-2 2-Brom-heptafluortoluol 
• 434-64-0 perfluorotoluene 
• 1442461-29-1 1,2,4,5-tetrafluoro-3-((4-methoxyphenyl)ethynyl)-6-(trifluoromethyl)benzene 
• 392-91-6 1,2,5-trifluoro-3-(trifluoromethyl)benzene 
• 393-38-4 2,5-difluoro(trifluoromethyl)benzene 
• 157766-28-4 2,3,4,5-tetraflurobenzotrichloride 
• 19113-94-1 Decafluorfluoren 

Relevant academic research and scientific papers

Transition-Metal-Free Catalytic Hydrodefluorination of Polyfluoroarenes by Concerted Nucleophilic Aromatic Substitution with a Hydrosilicate

A transition-metal-free catalytic hydrodefluorination (HDF) reaction of polyfluoroarenes is described. The reaction involves direct hydride transfer from a hydrosilicate as the key intermediate, which is generated from a hydrosilane and a fluoride salt. The eliminated fluoride regenerates the hydrosilicate to complete the catalytic cycle. Dispersion-corrected DFT calculations indicated that the HDF reaction proceeds through a concerted nucleophilic aromatic substitution (CSNAr) process.

Mechanistic studies of the rhodium NHC catalyzed hydrodefluorination of polyfluorotoluenes

The six-membered-ring NHC complexes Rh(6-NHC)(PPh3)2H (6-NHC = 6-iPr (1), 6-Et (2), 6-Me (3)) have been employed in the catalytic hydrodefluorination (HDF) of C6F5CF3 and 2-C6Fs

Halex reactions of aromatic compounds catalysed by 2-azaallenium, carbophosphazenium, aminophosphonium and diphosphazenium salts: A comparative study

An increasing number of biologically active compounds in the pharma and agro-chemical sector contain carbon fluorine bonds. One of the most common methods to introduce fluorine into intermediates is the well-investigated halogen-exchange reaction, in which chloro- and bromoaromatics activated towards nucleophilic substitution, react with a fluoride source to yield the corresponding fluoroarenes. In general, the reaction is supported by phase-transfer catalysts. The use of a new class of very active phase-transfer catalysts gives the possibility of substituting even halogens with weak activation giving a convenient access to interesting compounds that are not available so far and opening up new synthetic routes in Halex chemistry. Our new classes of catalysts, CNC+ (1a), PNC+ (2a) and several different approaches presented by other groups are described and experimental results discussed.

Process for the preparation of 2,3,4,5-tetrafluorobenzene derivatives

2,3,4,5-tetrafluorobenzene derivatives can be obtained in a particularly advantageous manner by reacting the corresponding chlorobenzene or (chloro, fluoro)-benzene derivatives with a fluorinating agent in the presence of a solvent and a catalyst at eleva