654075-03-3

Upstream product

• 654075-02-2 2,3-di-O-benzoyl-5-bromo-5-deoxy-D-ribofuranosyl acetate 
• 122-52-1 triethyl phosphite 

Downstream Products

• 120058-47-1 1-<5'-deoxy-2',3'-di-O-benzoyl-5'-(diethoxyphosphinyl)-β-D-ribofuranosyl>-4-benzamidopyrimidin-2-one 
• 120033-37-6 9-<5'-deoxy-2',3'-di-O-benzoyl-5'-(diethoxyphosphinyl)-β-D-ribofuranosyl>-2-bromohypoxanthine 
• 120033-35-4 9-<5'-deoxy-2',3'-di-O-benzoyl-5'-(diethoxyphosphinyl)-β-D-ribofuranosyl>-6-chloropurine 
• 594860-61-4 4-carbamoyl-1-[5-deoxy-2,3-di-O-benzyl-5-(diethoxyphosphinyl)-β-D-ribofuranosyl]-1,3-imidazolium-5-olate 
• 1337976-65-4 diethyl 2',3',6-tri-N,O-benzoyl-5'-deoxyadenosine-5'-C-ylphosphonate 
• 120033-38-7 9-<5'-deoxy-2',3'-di-O-benzoyl-5'-(diethoxyphosphinyl)-β-D-ribofuranosyl>hypoxanthine 
• 120033-36-5 1-<5'-deoxy-2',3'-di-O-benzoyl-5'-(diethoxyphosphinyl)-β-D-ribofuranosyl>uracil 

Relevant academic research and scientific papers

Antiviral phosphonate compounds and methods therefor

Pharmaceutical compositions comprise a nucleotide analog with a phosphonate group at a concentration effective to act as a substrate and/or inhibitor of a viral polymerase, and especially of the HCV RNA dependent RNA polymerase.

Synthesis and biological properties of purine and pyrimidine 5'-deoxy-5'-(dihydroxyphosphinyl)-β-D-ribofuranosyl analogues of AMP, GMP, IMP, and CMP

Methyl 2,3-O-isopropylidene-D-ribofuranoside (1) was converted to 1-O-acetyl-5-bromo-5-deoxy-2,3-di-O-benzoyl-D-ribofuranose (6) in five steps with good yield. The Arbuzov condensation of compound 6 with triethyl phosphite resulted in the synthesis of 1-O