120033-38-7

Upstream product

• 654075-02-2 2,3-di-O-benzoyl-5-bromo-5-deoxy-D-ribofuranosyl acetate 
• 654075-03-3 1-O-acetyl-2,3-di-O-benzoyl-5-deoxy-5-(diethoxyphosphinyl)-α-D-ribofuranose 
• 127211-14-7 2-Bromo-6-[2-(4-nitro-phenyl)-ethoxy]-9-trimethylsilanyl-9H-purine 
• 127244-78-4 2-bromo-6-(4-nitrophenylethoxy)purine 
• 87781-93-9 2-bromo-1,9-dihydro-6H-purin-6-one 
• 120033-37-6 9-<5'-deoxy-2',3'-di-O-benzoyl-5'-(diethoxyphosphinyl)-β-D-ribofuranosyl>-2-bromohypoxanthine 

Relevant academic research and scientific papers

Synthesis and biological properties of purine and pyrimidine 5'-deoxy-5'-(dihydroxyphosphinyl)-β-D-ribofuranosyl analogues of AMP, GMP, IMP, and CMP

Methyl 2,3-O-isopropylidene-D-ribofuranoside (1) was converted to 1-O-acetyl-5-bromo-5-deoxy-2,3-di-O-benzoyl-D-ribofuranose (6) in five steps with good yield. The Arbuzov condensation of compound 6 with triethyl phosphite resulted in the synthesis of 1-O

An Efficient Regioselective Synthesis of Substituted Purine Analogues of Guanosine and Inosine

Condensation of 2-bromo-6-(4-nitrophenylethoxy)purine as the trimethylsilyl derivative (5a) with 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose, 1-O-acetyl-2,3-di-O-benzoyl-5-deoxy-5-diethoxy-phosphinyl-β-D-ribofuranose, and (2-acetoxyethoxy)methyl bromide resulted in N9-regioselective alkylation to give (6a-c), which were then converted to guanine and hypoxanthine nucleosides, nucleotides, and Acyclovir analogues, respectively.