6546-65-2

Basic information

• Product Name: 4',5-diacetoxy-7-[hexa-O-acetyl-(2-O-α-L-rhamnopyranosyl-β-D-glucopyranosyl)oxy]flavone
• Synonyms: 4',5-diacetoxy-7-[hexa-O-acetyl-(2-O-α-L-rhamnopyranosyl-β-D-glucopyranosyl)oxy]flavone
• CAS NO: 6546-65-2
• Molecular Weight: 914.825
• Mol File: 6546-65-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4',5-diacetoxy-7-[hexa-O-acetyl-(2-O-α-L-rhamnopyranosyl-β-D-glucopyranosyl)oxy]flavone(CAS DataBase Reference)
• NIST Chemistry Reference: 4',5-diacetoxy-7-[hexa-O-acetyl-(2-O-α-L-rhamnopyranosyl-β-D-glucopyranosyl)oxy]flavone(6546-65-2)
• EPA Substance Registry System: 4',5-diacetoxy-7-[hexa-O-acetyl-(2-O-α-L-rhamnopyranosyl-β-D-glucopyranosyl)oxy]flavone(6546-65-2)

Safety Data

• Hazardous Substances Data: 6546-65-2(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 17306-46-6 rhoifolin 
• 10236-47-2 naringin 

Downstream Products

• 7404-35-5 1,2,3,4-tetra-O-acetyl-L-rhamnopyranose 
• 60815-39-6 apigenin 7-O-β-glucoside hexaacetate 
• 1415983-01-5 3-bromo-2-methoxyoctacetylnaringin 

Relevant articles and documents

Synthesis of acacetin and resveratrol 3,5-di-O-β-glucopyranoside using lipase-catalyzed regioselective deacetylation of polyphenol glycoside peracetates as the key step

Acacetin and resveratrol 3,5-di-O-β-glucopyranoside were synthesized from naturally abundant naringin and piceid in 65% and 62% overall yield, respectively. The key steps were the regioselective deacetylation of the peracetates of the glycosylated forms with Candida antarctica lipase B (Novozym 435) and Burkholderia cepacia lipase (Amano PS-IM). Deacetylation occurred exclusively at the least hindered position of the aromatic moieties and all acetyl groups in the sugar side chain remained intact. This excellent selectivity enabled regiospecific transformation of the liberated phenolic hydroxy groups, resulting in efficient synthesis of the target molecules.