6546-97-0

Upstream product

• 100-02-7 4-nitro-phenol 
• 65463-64-1 para-nitrophenyl phosphonate 
• 2524-64-3 chlorophosphoric acid diphenyl ester 
• 645-15-8 Bis(p-nitrophenyl) phosphate 

Downstream Products

• 29845-65-6 (4aR)-6t-(6-amino-purin-9-yl)-3-methyl-2ξ-(4-nitro-phenoxy)-2ξ-oxo-(4ar,7at)-hexahydro-2λ⁵-furo[2,3-e][1,3,2]oxazaphosphinin-7c-ol 
• 96413-67-1 quinolin-8-yl bis(p-nitrophenyl) phosphate 
• 120853-64-7 bis(p-nitrophenyl) 1-oxy-2,2,6,6-tetramethyl-4-piperidinyl phosphoramidate 
• 97280-42-7 N^α--L-alanyl-L-proline tert-butyl ester 
• 1384863-37-9 C₁₆H₁₆N₃O₉P 
• 97280-43-8 N^α-(bis(4-nitrophenoxy)phosphoryl)-L-alanyl-L-proline 

Relevant academic research and scientific papers

POLY(PHOSPHOESTERS) FOR DELIVERY OF NUCLEIC ACIDS

Disclosed are polymers comprising the moiety A, which is a moiety of formula I: and pharmaceutically acceptable salts thereof, wherein R, R1, R2, L, n1 and n2 are as defined herein. These polymers are useful for delivering nucleic acids to subject. These polymers and pharmaceutically acceptable compositions comprising such polymers and nucleic acids can be useful for treating various diseases, disorders and conditions.

Design and synthesis of novel active phosphonate esters and their application in preparation of ceftriaxone

For a series of active phosphonate esters, the anhydride abbreviated as ANPTA (6a) exhibits the highest reactivity in the preparation of ceftriaxone. The synthesis of ceftriaxone was optimized with the pilot-scale yield reaching 95.7%. The results were explained from the structural viewpoint and supported by analysis of the calculated Mulliken atomic charge distribution.

Synthesis and study of cyclic pronucleotides of 5-fluoro-2′- deoxyuridine

A one-step method for the synthesis of cyclic pronucleotide (cProTide) derivatives of 5-fluoro-2′-deoxyuridine (FdUrd), utilizing a novel phosphoramidating reagent, is described. Stereochemistry at phosphorus was established by NMR studies and modeling. C

Trichlorocyanuric acid: An efficient reagent for one-pot synthesis of Ptychodiscus brevis (PB-1) toxin and its derivatives

Trichlorocyanuric acid is an efficient regent for simple and one-pot synthesis of dialkyl, N-cycloctylphosphoraamidates (PB-1) and its various derivatives in excellent yields. The procedure is operationally simple and involves the reaction of various dialkylphosphites with trichloroisocyanuric acid in acetonitrile and subsequent treatment with amines in presence KF-celite to give PB-1 and derivatives.

Synthesis of Nitroxyl (Aminoxyl) Labeled Probes for Studies of Intracellular Environment by EPR and MRI

Syntheses are delineated for the following three classes of nitroxyl (aminoxyl) labeled active esters: (1) phosphoric acid derivatives containing phenyl and p-nitrophenyl moieties, (2) EDTA and DTPA containing acetoxymethyl and (pivaloyloxy)methyl as protecting groups, and (3) several amino acid derivatives containing the acetoxymethyl group.These compounds are expected to be of interest as potential probes in studies of intracellular environments by ESR spectroscopy and magnetic resonance imaging (MRI).