65462-22-8Relevant academic research and scientific papers
Total Synthesis of Indolizidine Alkaloids via Nickel-Catalyzed (4 + 2) Cyclization
Renner, Jonas,Thakur, Ashish,Rutz, Philipp M.,Cowley, Jacob M.,Evangelista, Judah L.,Kumar, Puneet,Prater, Matthew B.,Stolley, Ryan M.,Louie, Janis
supporting information, p. 924 - 928 (2020/02/04)
A Ni-catalyzed (4 + 2) cycloaddition of alkynes and azetidinones toward piperidinones was used as key reaction in the enantioselective synthesis of naturally occurring indolizidine alkaloids. The reaction benefits from the use of an easily accessible azet
An in Situ Approach to Nickel-Catalyzed Cycloaddition of Alkynes and 3-Azetidinones
Thakur, Ashish,Evangelista, Judah L.,Kumar, Puneet,Louie, Janis
, p. 9951 - 9958 (2015/11/03)
An efficient and convenient procedure that generates the active Ni(0) catalyst in situ from cheap, air stable Ni(II) precursors is developed for the [4 + 2]-cycloaddition of alkynes and 3-azetidinones. The reaction affords useful 3-dehydropiperidinones in
Application of an intramolecular dipolar cycloaddition to an asymmetric synthesis of the fully oxygenated tricyclic core of the stemofoline alkaloids
Carra, Ryan J.,Epperson, Matthew T.,Gin, David Y.
, p. 3629 - 3641 (2008/09/20)
An intramolecular non-stabilized azomethine ylide dipolar cycloaddition was applied toward the first non-racemic synthesis of the fully oxygenated bridged pyrrolizidine core (45) of (+)-stemofoline (1) in 11 steps from a commercially available starting material.
Enantiospecific synthesis of the bridged pyrrolizidine core of asparagamine A: Dipolar cycloadditions of azomethine ylides derived from the sulfonylation of vinylogous amides
Epperson, Matthew T.,Gin, David Y.
, p. 1778 - 1780 (2007/10/03)
An important precursor to the bridged pyrrolizidine core 2 of asparagamine A is vinylogous amide 1. The key reaction in the synthesis of 2 is an intramolecular 1,3-dipolar cycloaddition of an azomethine ylide derived from the sulfonylation of 1. A variety
