654653-37-9Relevant academic research and scientific papers
A novel selective aza-Morita-Baylis-Hillman (aza-MBH) domino reaction and aza-MBH reaction of N-sulfonated imines with acrolein catalyzed by a bifunctional phosphine organocatalyst
Meng, Xiangtai,Huang, You,Chen, Ruyu
supporting information; experimental part, p. 6852 - 6856 (2009/07/18)
An efficient, bifunctional phosphine organocatalyst catalyzed aza-MBH reaction and aza-MBH domino reaction was developed between N-sulfonated imines and acrolein under mild conditions in moderate to excellent yields. Acrolein was added to a solution of N-(2-chlorobenzylidene)-4-methylhenzenesulfonamide and catalyst LBBA in CHCl3. The stirring was maintained at room temperature until completion of the reaction. The residue was purified by a flash column chromatography to yield 3a as a colorless solid. The OH group is utilized to stabilize the intermediate A through hydrogen bonding. The Michael addition of A with N-sulfonated imine gives intermediate B, when THF is used as the solvent. The aza-MBH/Michael/aldol/dehydrate domino reaction also provides an efficient method to synthesize tetrahydropyridine derivatives, which can be used as building blocks in organic synthesis.
Highly Efficient aza-Baylis-Hillman Reaction of N-Tosylated Imines with MVK, Acrolein, and Phenyl Acrylate or α-Naphthyl Acrylate: Lewis Base Effects and A Convenient Method to Synthesize α,β-Unsaturated β-Amino Carbonyl Compounds
Xu, Yong-Mei,Shi, Min
, p. 417 - 425 (2007/10/03)
This paper describes several highly efficient aza-Baylis-Hillman reactions of N-tosylated imines with MVK, acrolein, and phenyl acrylate or α-naphthyl acrylate in the presence of a Lewis base. In most cases, the reaction can be completed within 1 h using
