654666-07-6Relevant articles and documents
Restriction of a Peptide Turn Conformation and Conformational Analysis of Guanidino Group Using Arginine-Proline Fused Amino Acids: Application to Mini Atrial Natriuretic Peptide on Binding to the Receptor
Sugase, Kenji,Horikawa, Manabu,Sugiyama, Masako,Ishiguro, Masaji
, p. 489 - 492 (2007/10/03)
Compounds (2S,4S)- and (2S,4R)-4-(2′-guanidinoethyl)proline have been synthesized as a conformationally restricted arginine, Their backbones fit the i + 1 position in a turn, and the side chains are restricted compared to that of arginine. These analogues were incorporated into mini atrial natriuretic polypeptide, which has an important turnlike conformation at Gly6-Arg7-Met8-Asp9. Structural analysis revealed that the size of the conformational space of Arg7 on binding to the receptor was approximately one-third of the entire conformational space.