655230-84-5Relevant academic research and scientific papers
Intramolecular addition of benzylic radicals onto ketenimines. Synthesis of 2-alkylindoles
Alajarin, Mateo,Vidal, Angel,Ortin, Maria-Mar
, p. 4282 - 4292 (2007/10/03)
The inter- and intramolecular addition of free radicals onto ketenimines is studied. All the attempts to add intermolecularly several silicon, oxygen or carbon centered radicals to N-(4-methylphenyl)-C,C-diphenyl ketenimine were unsuccessful. In contrast, the intramolecular addition of benzylic radicals, generated from xanthates, onto the central carbon of a ketenimine function with its N atom linked to the ortho position of the aromatic ring occurred under a variety of reaction conditions. These intramolecular cyclizations provide a novel radical-mediated synthesis of 2-alkylindoles.
