655248-82-1Relevant articles and documents
New fibrinolytic agents: Benzothiophene derivatives as inhibitors of the t-PA-PAI-1 complex formation
De Nanteuil, Guillaume,Lila-Ambroise, Christine,Rupin, Alain,Vallez, Marie-Odile,Verbeuren, Tony J.
, p. 1705 - 1708 (2007/10/03)
The synthesis and activity of novel benzothiophene derivatives are described. In the t-Pa-induced fibrin clot lysis assay, several compounds inhibit the formation of the tPa-PAI-1 complex with submicromolar IC50. This class of compounds potentially represents a new generation of antithrombotic-fibrinolytic agents.