6553-85-1Relevant academic research and scientific papers
β-Arylation of carboxamides via iron-catalyzed C(sp3)-H bond activation
Shang, Rui,Ilies, Laurean,Matsumoto, Arimasa,Nakamura, Eiichi
supporting information, p. 6030 - 6032,3 (2013/05/22)
A 2,2-disubstituted propionamide bearing an 8-aminoquinolinyl group as the amide moiety can be arylated at the β-methyl position with an organozinc reagent in the presence of an organic oxidant, a catalytic amount of an iron salt, and a biphosphine ligand at 50 C. Various features of selectivity and reactivity suggest the formation of an organometallic intermediate via rate-determining C-H bond cleavage rather than a free-radical-type reaction pathway.
