1892-09-7

Upstream product

• 31151-40-3 2-cyclohexyl-1-diazo-2-ethanone 
• 79-04-9 chloroacetyl chloride 
• 110-83-8 cyclohexene 
• 57741-18-1 trimethyl(2,2,2-trichloro-1-cyclohexylethoxy)silane 
• 186581-53-3 diazomethane 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 55629-29-3 cyclohexyl (trimethylsilyl)methyl ketone 
• 98-89-5 Cyclohexanecarboxylic acid 
• 57741-12-5 α-(trichloromethyl)cyclohexanemethanol 
• 14352-61-5 methyl cyclohexylacetate 
• 3926-62-3 sodium monochloroacetic acid 
• 931-48-6 2-cyclohexylacetylene 
• 67442-07-3 2-chloro-N-methoxy-N-methylacetamide 
• 931-51-1 cyclohexylmagnesiumchloride 

Downstream Products

• 825-04-7 methyl 1-methylcyclohexanecarboxylate 
• 104672-17-5 4-cyclohexyl-1⁽³⁾H-imidazole 
• 54248-57-6 2-(cyclohexyl)hex-1-ene 
• 31151-34-5 1-Cyclohexyl-2-chlor-1,3-butandion 
• 31180-45-7 Acetic acid (E)-2-chloro-1-cyclohexyl-vinyl ester 
• 39184-49-1 1-cyclohexyl-1-methylcarbamyloximino-2-methylthioethane 
• 1037835-01-0 1-[1-(2-cyclohexyl-2-oxoethyl)piperidin-4-yl]-5-(methylsulfonyl)-1,3-dihydro-2H-benzimidazol-2-one 
• 1037834-15-3 1-[1-(2-cyclohexyl-2-oxoethyl)piperidin-4-yl]-6-fluoro-N-methyl-2-oxo-2,3-dihydro-1H-benzimidazole-5-carboxamide 
• 90202-27-0 (+/-)-2-chloro-1-cyclohexylethanol 
• 31151-35-6 ((E)-2-Chloro-1-cyclohexyl-vinyloxy)-trimethyl-silane 
• 6004-53-1 1-cyclohexyl-2-hydroxyethanone 
• 86409-79-2 (1-deuteriovinyl)cyclohexane 
• 695-12-5 vinylcyclohexane 
• 86409-75-8 (2-cyclohexylallyl)benzene 

Relevant academic research and scientific papers

Photoenzymatic Synthesis of α-Tertiary Amines by Engineered Flavin-Dependent "ene"-Reductases

α-Tertiary amines are a common motif in pharmaceutically important molecules but are challenging to prepare using asymmetric catalysis. Here, we demonstrate engineered flavin-dependent ‘ene'-reductases (EREDs) can catalyze radical additions into oximes to prepare this motif. Two different EREDs were evolved into competent catalysts for this transformation with high levels of stereoselectivity. Mechanistic studies indicate that the oxime contributes to the enzyme templated charge-transfer complex formed between the substrate and cofactor. These products can be further derivatized to prepare a variety of motifs, highlighting the versatility of ERED photoenzymatic catalysis for organic synthesis.

Facile and efficient preparation of α-halomethyl ketones from α-diazo ketones catalyzed by iron(III) halides and silica gel

An efficient and mild method for the synthesis of α-halomethyl ketones from α-diazo ketones was developed using ferric chloride or bromide as the halogen source and silica gel as the hydrogen source, with good to excellent yields.

Electrophilicity of α-oxo gold carbene intermediates: Halogen abstractions from halogenated solvents leading to the formation of chloro/bromomethyl ketones

α-Oxo gold carbenes generated via intermolecular oxidation of terminal alkynes are shown to be highly electrophilic and can effectively abstract halogen from halogenated solvents such as 1,2-dichloroethane or 1,2-dibromoethane. Chloro/bromomethyl ketones are prepared in moderate efficiencies in one step using Ph3PAuNTf2 as the catalyst and 8-methylquinoline N-oxide as the oxidant.

Empirical method for predicting enantioselectivity in catalytic reactions: demonstration with lipase and oxazaborolidine

We derived a novel equation capable of predicting the degree of enantioselectivity in a catalytic reaction without any knowledge of the reaction mechanism and/or the transition-state structure, and tested the validity of this equation by changing substrates systematically in the lipase or oxazaborolidine-catalyzed reactions. A good correlation was observed between the predicted and observed E values, and the stereochemistry of the products could be predicted correctly in most cases (28 out of 30).

INHIBITORS OF SERINE PALMITOYLTRANSFERASE

This invention provides compounds of the formula (I) useful in the inhibition or modulation of serine palmitoyl transferase and their use in methods of treatment or amelioration of type 2 diabetes, type 1 diabetes, insulin resistance, the effects of obesity, metabolic syndrome (sometimes referred to as Syndrome X), impaired glucose tolerance, Cushing's disease, cardiovascular disease, prothrombotic conditions, myocardial infarction, hypertension, congestive heart failure, cardiomyopathy, atherosclerosis, dyslipidemia, sepsis, liver damage, retinal degenerative disorders, cachexia, emphysema, hepatitis C infections, HIV infections and inflammatory disorders and useful in methods for raising HDL plasma levels in a mammal. The compounds of this invention can also be used to prevent damage or loss of pancreatic islet beta cells (such as in the case of pancreatic beta cell apoptosis, including those related to insulin-dependent diabetes mellitus).

Novel cyclic amide derivatives

Novel compounds represented by the following formula (I) that act as a ligand to sigma receptor/binding cite and a medicament comprising the same as an active ingredient: wherein X represents an alkyl group, an aryl group, a heterocyclic group or the like; Q represents a group represented by —CH2—, —CO—, —O—, —CH(OR7)— or the like wherein R7 represents a hydrogen atom, an alkyl group or the like; n represents an integer of from 0 to 5; R1 and R2 each represent a hydrogen atom, an alkyl group or the like; B represents either of the following groups: wherein R3, R4, R5, and R6 each represent a hydrogen atom, a halogen atom, an alkoxyl group or the like; m represents 1 or 2; and the ring of: represents an aromatic heterocyclic ring.